The role of matrix metalloproteinase9 in atherosclerotic plaque instability

T Li, X Li, Y Feng, G Dong, Y Wang… - Mediators of …, 2020 - Wiley Online Library
Matrix metalloproteinase9 (MMP9) belongs to the MMP family and has been widely
investigated. Excessive MMP9 expression can enhance extracellular matrix degradation …

Periodontal therapeutics: Current hostmodulation agents and future directions

LM Golub, HM Lee - Periodontology 2000, 2020 - Wiley Online Library
With the recognition in the 1960s and 1970s of the periodontopathic importance of the
microbial biofilm and its specific anaerobic microorganisms, periodontitis was treated as an …

Metalloproteinases in atherosclerosis

JL Johnson - European journal of pharmacology, 2017 - Elsevier
Atherosclerosis underlies most cardiovascular diseases, and is accepted as a primary cause
of mortality worldwide. Proteases have been implicated in the development and progression …

Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function

FG Spinale - Physiological reviews, 2007 - journals.physiology.org
It is now becoming apparent that dynamic changes occur within the interstitium that directly
contribute to adverse myocardial remodeling following myocardial infarction (MI), with …

Matrix metalloproteinases: contribution to pathogenesis, diagnosis and treatment of periodontal inflammation

T Sorsa, L Tjäderhane, YT Konttinen, A Lauhio… - Annals of …, 2006 - Taylor & Francis
Matrix metalloproteinases (MMPs) form a family of enzymes that mediate multiple functions
both in the tissue destruction and immune responses related to periodontal inflammation …

Poly (ADP-ribose) polymerase (PARP) and PARP inhibitors: mechanisms of action and role in cardiovascular disorders

RJ Henning, M Bourgeois, RD Harbison - Cardiovascular toxicology, 2018 - Springer
Poly (ADP-ribosyl) ation is an immediate cellular repair response to DNA damage and is
catalyzed primarily by poly (ADP-ribose) polymerase-1 (PARP1), which is the most …

Future biomarkers for detection of ischemia and risk stratification in acute coronary syndrome

FS Apple, AHB Wu, J Mair, J Ravkilde… - Clinical …, 2005 - academic.oup.com
Background: Evaluation of patients who present to the hospital with a complaint of chest
pain or other signs or symptoms suggestive of acute coronary syndrome (ACS) is time …

Matrix metalloproteinases in coronary artery disease and myocardial infarction

H Bräuninger, S Krüger, L Bacmeister… - Basic Research in …, 2023 - Springer
Cardiovascular diseases (CVDs) remain the leading cause of death worldwide. Most
cardiovascular deaths are caused by ischaemic heart diseases such as myocardial …

Divergent effects of matrix metalloproteinases 3, 7, 9, and 12 on atherosclerotic plaque stability in mouse brachiocephalic arteries

JL Johnson, SJ George, AC Newby… - Proceedings of the …, 2005 - National Acad Sciences
Matrix metalloproteinases (MMPs) are thought to be involved in the growth, destabilization,
and eventual rupture of atherosclerotic lesions. Using the mouse brachiocephalic artery …

Doxycycline as an antiinflammatory agent: updates in dermatology

M Henehan, M Montuno… - Journal of the European …, 2017 - Wiley Online Library
Doxycycline, a tetracycline antibiotic, is widely used in the field of dermatology for its
antibiotic properties, antiinflammatory properties and good safety profile. Over the past …