Simple Summary Despite the adoption of aggressive, multimodal treatment schedules, the
cure rate of high-grade osteosarcoma (HGOS) has not significantly improved in the last 30 …

The bone is a complex connective tissue composed of many different cell types such as
osteoblasts, osteoclasts, chondrocytes, mesenchymal stem/progenitor cells, hematopoietic …

Long noncoding RNAs (lncRNAs) are a class of non-protein-coding molecules longer than
200 nucleotides that are involved in the development and progression of many types of …

Glioblastomas are the most prevalent and lethal primary brain tumor and are comprised of
hierarchies with self-renewing cancer stem cells (CSCs) at the apex. Like neural stem cells …

Osteosarcoma is the most common type of bone cancer, especially in children and young
adults. The primary treatment for osteosarcoma is a combination of surgery and …

Activin A receptor type I (ACVR1) encodes for a bone morphogenetic protein type I receptor
of the TGFβ receptor superfamily. It is involved in a wide variety of biological processes …

Aim: To analyze the m6A methylome of osteosarcoma stem cells (OSCs). Materials &
methods: Chemoresistant OSCs were enriched by doxorubicin treatment. Expression of m6A …

Abstract Bone morphogenetic protein 2 (BMP-2) has been reported to facilitate epithelial-to-
mesenchymal transition (EMT) and bone metastasis in breast cancer xenograft models. To …

Bone morphogenetic proteins (BMPs) play important roles in embryonic and postnatal
development by regulating cell differentiation, proliferation, motility, and survival, thus …

Osteosarcoma (OS) is a malignancy that is becoming increasingly common in adolescents.
OS stem cells (OSCs) form a dynamic subset of OS cells that are responsible for malignant …