Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Endocytic mechanisms control the lipid and protein composition of the plasma membrane,
thereby regulating how cells interact with their environments. Here, we review what is known …

Filopodia are thin, actin-rich plasma-membrane protrusions that function as antennae for
cells to probe their environment. Consequently, filopodia have an important role in cell …

Dual colour total internal reflection fluorescence microscopy is a powerful tool for decoding
the molecular dynamics of clathrin-mediated endocytosis (CME). Typically, the recruitment of …

Generating force and movement is essential for the functions of cells and organisms. A
variety of molecular motors that can move on tracks within cells have evolved to serve this …

Autophagy targets pathogens, damaged organelles and protein aggregates for lysosomal
degradation. These ubiquitylated cargoes are recognized by specific autophagy receptors …

Autophagy plays a key role during Salmonella infection, by eliminating these pathogens
following escape into the cytosol. In this process, selective autophagy receptors, including …

As the unique cell type in articular cartilage, chondrocyte senescence is a crucial cellular
event contributing to osteoarthritis development. Here we show that clathrin-mediated …

Myosins are a large family of actin-based cytoskeletal motors that use energy derived from
ATP hydrolysis to generate movement and force. Myosins of classes II, V and VI have …

Three types of motors, myosins, kinesins, and cytoplasmic dynein, cooperate to transport
intracellular membrane organelles. Transport of each cargo is determined by recruitment of …