The liver controls the systemic exposure of amino acids entering via the gastro-intestinal
tract. For most amino acids except branched chain amino acids, hepatic uptake is very …

Translation of cellular mRNAs via initiation at Internal Ribosome Entry Sites (IRESs) has
received increased attention during recent years due to its emerging significance for many …

Mammals respond to dietary nutrient fluctuations; for example, deficiency of dietary protein
or an imbalance of essential amino acids activates an amino acid response (AAR) signal …

Transporters of the SLC38 family are found in all cell types of the body. They mediate Na+-
dependent net uptake and efflux of small neutral amino acids. As a result they are …

Amino acid (AA) transporters may act as sensors, as well as carriers, of tissue nutrient
supplies. This review considers recent advances in our understanding of the AA-sensing …

Amino acid transporters at the surface of cells are in an ideal location to relay nutritional
information, as well as nutrients themselves, to the cell interior. These transporters are able …

The glutamine transporter ASCT2 (SLC1A5) is actively investigated as an oncological target,
but the field lacks efficient ASCT2 inhibitors. A new group of ASCT2 inhibitors, 2-amino-4-bis …

Essential amino acids (EAA) stimulate skeletal muscle mammalian target of rapamycin
complex 1 (mTORC1) signaling and protein synthesis. It has recently been reported that an …

About 25% of all solute carriers (SLCs) are likely to transport amino acids as their primary
substrate. One of the major phylogenetic clusters of amino acid transporters from the SLC …

Amino acid transporters and mammalian target of rapamycin complex 1 (mTORC1)
signaling are important contributors to muscle protein anabolism. Aging is associated with …