Publisher Summary This chapter discusses the role of plasminogen activators in various
biological processes. In specific, it describes two types of plasminogen activators—namely …

The invasion of normal tissues and penetration of basement membranes by malignant cells
is likely to require the active participation of hydrolytic enzymes. The four major groups of …

The synthesis of plasminogen activator (PA) by cultured human embryonic lung (HuEL) cells
has been examined. The production of PA by these cells was found to be reversibly inhibited …

Primary cultures of rat hepatocytes survived well for up to 4 days in defined medium in the
presence of dexamethasone but not in its absence. The loss of viability was accompanied by …

Following treatment of Syrian hamster embryo cells with benzo (a) pyrene, the time required
for the expression of enhanced fibrinolytic activity was examined. For this study, the fibrin …

In the last few years increased release of fibrinolytic enzymes from malignant cells has been
observed, but the significance of this property in relation to malignant growth is still not fully …

We have compared the abilities of retinoic acid to modify the fibrinolytic activity, the
anchorage-dependent growth and the anchorage-independent growth of various cultured …

Publisher Summary In this chapter, a number of mechanisms have been suggested to
explain the process of tumor cell invasion in terms of observed properties of neoplastic cells …

The use of cell culture systems for the study of chemical carcinogenesis was given impetus
by the demonstration of Berwald and Sachs in 1963 that primary rodent embryo cells could …

Virally transformed cells show an increased production of proteolytic enzymes. These might
be involved in transformation-dependent alterations of cell surface glycoproteins. The …