Vital internal organs display a left-right (LR) asymmetric arrangement that is established
during embryonic development. Disruption of this LR asymmetry—or laterality—can result in …

The systematic breaking of left–right body symmetry is a familiar feature of human
physiology. In humans and many animals, this process originates with asymmetric fluid flow …

Rab and Arl guanine nucleotide‐binding (G) proteins regulate trafficking pathways essential
for the formation, function and composition of primary cilia, which are sensory devices …

Fluid flows generated by motile cilia are guiding the establishment of the left-right asymmetry
of the body in the vertebrate left-right organizer. Competing hypotheses have been …

Foxj1a is necessary and sufficient to specify motile cilia. Using transcriptional studies and
slow-scan two-photon live imaging capable of identifying the number of motile and immotile …

The left-right organizer in zebrafish embryos, Kupffer's Vesicle (KV), is a simple organ that
undergoes programmed asymmetric cell shape changes that are necessary to establish the …

Zebrafish is a vertebrate teleost widely used in many areas of research. As embryos, they
develop quickly and provide unique opportunities for research studies owing to their …

Reduction in the length of motile cilia in the zebrafish left–right organizer (LRO), also known
as Kupffer's vesicle, has a large impact on left–right development. Here we demonstrate …

How is sensing carried out by cilia in the mouse node, zebrafish Kupffer's vesicle and similar
left–right (LR) organizer organs in other species? Two possibilities have been put forward. In …

In certain vertebrate species, the developing embryo breaks left-right symmetry in a transient
organising structure: the “Left-Right Organiser”(LRO) known as the “node” in mice, and …