Wu Wei Zi is the dried fruit of Schisandra chinensis (Turcz.) Baill. or Schisandra
sphenanthera Rehd. et Wils.(family Magnoliaceae). As a homology of medicine and food, it …

Tacrolimus is an immunosuppressive calcineurin inhibitor used to prevent rejection in
allogeneic organ transplant recipients, such as kidney, liver, heart or lung. It is metabolized …

We recently reported that Wuzhi tablet (WZ; Schisandra sphenanthera extract) can inhibit P-
glycoprotein (P-gp)–mediated efflux and CYP3A-mediated metabolism of tacrolimus …

Schisantherin A and schisandrin A, the most abundant active ingredients of Wuzhi capsule,
are known to inhibit tacrolimus metabolism by inhibiting CYP 3A4/5. We aimed to predict the …

We previously reported that the ethanol extract of Schisandra sphenanthera [Wuzhi (WZ)
tablet] significantly protects against acetaminophen-induced hepatoxicity. However, whether …

We recently reported that Wuzhi tablet (WZ), a preparation of the ethanol extract of Wuweizi
(Schisandra sphenanthera), had significant effects on blood concentrations of Tacrolimus …

Herb medicine has a long history of application and is still used worldwide. With the
development of complementary and alternative medicine, the interaction between herb and …

Tacrolimus is a potent but expensive first-line immunosuppressant, thus solutions to reduce
tacrolimus consumption while maintain therapeutic level are in urgent need. A two-phase …

What is known and objective Tacrolimus (FK506), an effective and potent calcineurin
inhibitor, is the cornerstone of immunosuppression after kidney transplantation. Wuzhi …

The calcineurin inhibitor tacrolimus (TAC) shows inter-and intra-individual variability in
blood levels and has a narrow therapeutic index. To reduce the chance of fluctuations in …