Myelin is critical for the proper function of the nervous system and one of the most complex
cell–cell interactions of the body. Myelination allows for the rapid conduction of action …

Abstract Neuregulin-1 (Nrg-1) is a member of the Neuregulin family of growth factors with
essential roles in the developing and adult nervous system. Six different types of Nrg-1 (Nrg …

Peripheral nerves and Schwann cells have to sustain constant mechanical constraints,
caused by developmental growth as well as stretches associated with movements of the …

Abstract Charcot‐Marie‐Tooth (CMT) neuropathies are one of the most common
neuromuscular disorders. However, despite the identification of more than 100 causative …

Schwann cells play a critical role in the development of the peripheral nervous system
(PNS), establishing important relationships both with the extracellular milieu and other cell …

YAP and TAZ are effectors of the Hippo pathway that controls multicellular development by
integrating chemical and mechanical signals. Peripheral nervous system development …

Axonal demyelination is a consistent pathological characteristic of Spinal cord injury (SCI).
Promoting differentiation of oligodendrocytes is of importance for remyelination. Conversion …

Myelin is essential for rapid nerve impulse propagation and axon protection. Accordingly,
defects in myelination or myelin maintenance lead to secondary axonal damage and …

Axons share a close relationship with Schwann cells, their glial partners in peripheral
nerves. An intricate axo‐glia network of signals and bioactive molecules regulates the major …

After damage, axons in the peripheral nervous system (PNS) regenerate and regrow
following a process termed Wallerian degeneration, but the regenerative process is often …