Recombinant proteins are becoming increasingly important for industrial applications, where
Escherichia coli is the most widely used bacterial host for their production. However, the …

Bacterial inclusion bodies (IBs) are functional, non-toxic amyloids occurring in recombinant
bacteria showing analogies with secretory granules of the mammalian endocrine system …

The purpose of this work was to construct a consensus prediction algorithm of 'aggregation-
prone'peptides in globular proteins, combining existing tools. This allows comparison of the …

The amyloid state of protein organization is typically associated with debilitating human
neuropathies and is seldom observed in physiology. Here, we uncover a systemic program …

In Alzheimer's disease, neurons slowly degenerate due to the accumulation of misfolded
amyloid β and tau proteins. In our research, we performed extended studies directed at …

Enzymes are used as biocatalysts in a vast range of industrial applications. Immobilization of
enzymes to solid supports or their self-assembly into insoluble particles enhances their …

The formation of inclusion bodies (IBs) constitute a frequent event during the production of
heterologous proteins in bacterial hosts. Although the mechanisms leading to their formation …

The bacterium Escherichia coli is a major host for recombinant protein production of non-
glycosylated products. Depending on the expression strategy, the recombinant protein can …

High-level expression of recombinant proteins in Escherichia coli often results in
accumulation of protein molecules into aggregates known as inclusion bodies (IBs) …

Liquid–liquid phase separation (LLPS) and the formation of membraneless organelles
(MLOs) contribute to the spatiotemporal organization of various physiological processes in …