Risk factors and prevention of hepatocellular carcinoma in the era of precision medicine

N Fujiwara, SL Friedman, N Goossens, Y Hoshida - Journal of hepatology, 2018 - Elsevier
Patients who develop chronic fibrotic liver disease, caused by viral or metabolic aetiologies,
are at a high risk of developing hepatocellular carcinoma (HCC). Even after complete HCC …

Pathogenesis and current treatment strategies of hepatocellular carcinoma

D Tümen, P Heumann, K Gülow, CN Demirci… - Biomedicines, 2022 - mdpi.com
Hepatocellular carcinoma (HCC) is the most frequent liver cancer with high lethality and low
five-year survival rates leading to a substantial worldwide burden for healthcare systems …

The trends in incidence of primary liver cancer caused by specific etiologies: results from the Global Burden of Disease Study 2016 and implications for liver cancer …

Z Liu, Y Jiang, H Yuan, Q Fang, N Cai, C Suo, L Jin… - Journal of …, 2019 - Elsevier
Background & Aims Liver cancer is a common malignant neoplasm worldwide. The
etiologies for liver cancer are diverse and the incidence trends of liver cancer caused by …

Fibrosis severity as a determinant of cause-specific mortality in patients with advanced nonalcoholic fatty liver disease: a multi-national cohort study

E Vilar-Gomez, L Calzadilla-Bertot, VWS Wong… - Gastroenterology, 2018 - Elsevier
Background & Aims Little is known about the natural course of nonalcoholic fatty liver
disease (NAFLD) with advanced fibrosis. We describe long-term outcomes and evaluate the …

Classification and mutation prediction based on histopathology H&E images in liver cancer using deep learning

M Chen, B Zhang, W Topatana, J Cao, H Zhu… - NPJ precision …, 2020 - nature.com
Hepatocellular carcinoma (HCC) is the most common subtype of liver cancer, and assessing
its histopathological grade requires visual inspection by an experienced pathologist. In this …

Epidemiological and etiological variations in hepatocellular carcinoma

E Sagnelli, M Macera, A Russo, N Coppola, C Sagnelli - Infection, 2020 - Springer
Background Hepatocellular carcinoma (HCC) is the most prevalent form of liver cancer and
a leading cause of cancer-related deaths worldwide. The major risk factors for HCC …

[HTML][HTML] HCC risk stratification after cure of hepatitis C in patients with compensated advanced chronic liver disease

G Semmler, EL Meyer, K Kozbial, P Schwabl… - Journal of …, 2022 - Elsevier
Background & Aims Hepatocellular carcinoma (HCC) is a major cause of morbidity and
mortality in patients with advanced chronic liver disease (ACLD) caused by chronic hepatitis …

Global incidence trends in primary liver cancer by age at diagnosis, sex, region, and etiology, 1990‐2017

Z Liu, C Suo, X Mao, Y Jiang, L Jin, T Zhang, X Chen - Cancer, 2020 - Wiley Online Library
Background The incidence of primary liver cancer (PLC) continues to increase worldwide.
The incidence trends and patterns of PLC associated with different age at diagnosis remain …

The role of transjugular intrahepatic portosystemic shunt in patients with cirrhosis and ascites: recent evolution and open questions

P Deltenre, A Zanetto, D Saltini, C Moreno… - Hepatology, 2023 - journals.lww.com
In selected patients with cirrhosis and ascites, transjugular intrahepatic portosystemic shunt
(TIPS) placement improves control of ascites and may reduce mortality. In this review, we …

New therapeutics for HCC: Does tumor immune microenvironment matter?

A Khanam, S Kottilil - International Journal of Molecular Sciences, 2022 - mdpi.com
The incidence of liver cancer is continuously rising where hepatocellular carcinoma (HCC)
remains the most common form of liver cancer accounting for approximately 80–90% of the …