Succinate dehydrogenase (SDH), also named as complex II or succinate: quinone
oxidoreductases (SQR) is a critical enzyme in bioenergetics and metabolism. This is …

Metabolic programs can differ substantially across genetically distinct subtypes of acute
myeloid leukemia (AML). These programs are not static entities but can change swiftly as a …

Succinylation is a post-translational protein acylation modification that converts the cationic
lysine side chain to an anion with large potential impacts on protein structure and function …

The study of tumorigenic rewiring of metabolic flux is at the heart of cancer metabolic
research. Here, we review two widely used computational flux inference approaches …

Reduced skeletal muscle mass and oxidative capacity coexist in patients with pulmonary
emphysema and are independently associated with higher mortality. If reduced cellular …

Acute myeloid leukemia (AML) is a hematologic malignancy metabolically dependent on
oxidative phosphorylation and mitochondrial electron transport chain (ETC) activity. AML …

Synthetic Lethality (SL) is currently defined as a type of genetic interaction in which the loss
of function of either of two genes individually has limited effect in cell viability but inactivation …

Mutations in any of the genes encoding the four subunits of succinate dehydrogenase
(SDH), a mitochondrial membrane‐bound enzyme complex that is involved in both the …

Heterozygosity for loss-of‐function alleles of the genes encoding the four subunits of
succinate dehydrogenase (SDHA, SDHB, SDHC, SDHD), as well as the SDHAF2 assembly …

Patients with pulmonary emphysema often develop locomotor muscle dysfunction, which is
independently associated with disability and higher mortality in that population. Muscle …