The Neurotherapeutic Arsenal in Cannabis sativa: Insights into Anti-Neuroinflammatory and Neuroprotective Activity and Potential Entourage Effects

AK Al-Khazaleh, X Zhou, DJ Bhuyan, GW Münch… - Molecules, 2024 - mdpi.com
Cannabis, renowned for its historical medicinal use, harbours various bioactive compounds—
cannabinoids, terpenes, and flavonoids. While major cannabinoids like delta-9 …

[HTML][HTML] Kidney-brain axis in the pathogenesis of cognitive impairment

Q Yan, M Liu, Y Xie, Y Lin, P Fu, Y Pu, B Wang - Neurobiology of Disease, 2024 - Elsevier
The kidney-brain axis is a bidirectional communication network connecting the kidneys and
the brain, potentially affected by inflammation, uremic toxin, vascular injury, neuronal …

Quercetin increases the antidepressant‐like effects of sclareol and antagonizes diazepam in thiopental sodium‐induced sleeping mice: a possible GABAergic …

MH Bappi, MN Mia, SA Ansari, IA Ansari… - Phytotherapy …, 2024 - Wiley Online Library
Quercetin is the most common polyphenolic flavonoid present in fruits and vegetables
demonstrating versatile health‐promoting effects. This study aimed to examine the effects of …

Anti-inflammatory effects of thymol: an emphasis on the molecular interactions through in vivo approach and molecular dynamic simulations

MT Islam, MH Bappi, MS Bhuia, SA Ansari… - Frontiers in …, 2024 - frontiersin.org
Thymol (THY), as the natural monoterpene phenol, acts against oxidative stress and
inflammatory processes. This study aimed to evaluate the anti-inflammatory effects and …

Genus Pimenta: An Updated Comprehensive Review on Botany, Distribution, Ethnopharmacology, Phytochemistry and Biological Approaches

HAS El‐Nashar, AAM Ali, YH Salem - Chemistry & Biodiversity, 2023 - Wiley Online Library
Pimenta is a genus of flowering plants belonging to family Myrtaceae, native to the West
Indies, Mexico, and South America. Numerous traditional uses were reported as anti …

Trace elements and metal nanoparticles: mechanistic approaches to mitigating chemotherapy-induced toxicity—a review of literature evidence

AC Famurewa, MY George, CA Ukwubile, S Kumar… - BioMetals, 2024 - Springer
Anticancer chemotherapy (ACT) remains a cornerstone in cancer treatment, despite
significant advances in pharmacology over recent decades. However, its associated side …

[HTML][HTML] Sclareol antagonizes the sedative effect of diazepam in thiopental sodium-induced sleeping animals: In vivo and in silico studies

SMH Hassan, HAS El-Nashar, MA Rahman… - Biomedicine & …, 2024 - Elsevier
Background Sclareol (SCL), a labdane diterpene compound found in Salvia sclarea L.,
exhibited therapeutic effects. This study investigated the potential interaction between SCL …

LC-qTOF-MS/MS phytochemical profiling of Tabebuia impetiginosa (Mart. Ex DC.) Standl. leaf and assessment of its neuroprotective potential in rats

N Khaled, N Ibrahim, AE Ali, FS Youssef… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Tabebuia impetiginosa (Bignoniaceae) was
traditionally used for memory enhancement and central nervous system (CNS) stimulation …

Potential of Natural Phenolic Compounds against Doxorubicin-Induced Chemobrain: Biological and Molecular Mechanisms Involved

S Serini, G Calviello - Antioxidants, 2024 - mdpi.com
Chemotherapy-induced cognitive impairment or “chemobrain” is a prevalent long-term
complication of chemotherapy and one of the more devastating. Most of the studies …

Bromelain as a natural anti-inflammatory drug: a systematic review

T Alves Nobre, AA de Sousa, IC Pereira… - Natural Product …, 2024 - Taylor & Francis
Inflammation is a complex and necessary mechanism of an organ's response to biological,
chemical and/or physical stimuli. In recent years, investigations on natural compounds with …