Quantitative rotating frame relaxometry methods in MRI

IA Gilani, R Sepponen - NMR in Biomedicine, 2016 - Wiley Online Library
Macromolecular degeneration and biochemical changes in tissue can be quantified using
rotating frame relaxometry in MRI. It has been shown in several studies that the rotating …

Multiparametric MRI assessment of human articular cartilage degeneration: Correlation with quantitative histology and mechanical properties

J Rautiainen, MJ Nissi, EN Salo, V Tiitu… - Magnetic resonance …, 2015 - Wiley Online Library
Purpose To evaluate the sensitivity of quantitative MRI techniques (T1, T1, Gd, T2, continous
wave (CW) T1ρ dispersion, adiabatic T1ρ, adiabatic T2ρ, RAFF and inversion‐prepared …

Downregulation of VEGFR3 signaling alters cardiac lymphatic vessel organization and leads to a higher mortality after acute myocardial infarction

T Vuorio, E Ylä-Herttuala, JP Laakkonen, S Laidinen… - Scientific reports, 2018 - nature.com
Heart has a wide lymphatic network but the importance of cardiac lymphatic system in heart
diseases has remained unclear. Vascular Endothelial Growth Factor Receptor 3 (VEGFR3) …

[HTML][HTML] Quantitative neuroimaging in mucopolysaccharidoses clinical trials

I Nestrasil, L Vedolin - Molecular genetics and metabolism, 2017 - Elsevier
The mucopolysaccharidosis (MPS) disorders are rare lysosomal storage disorders caused
by mutations in lysosomal enzymes involved in glycosaminoglycan (GAG) degradation. The …

Relaxation anisotropy of quantitative MRI parameters in biological tissues

NE Hänninen, T Liimatainen, M Hanni, O Gröhn… - Scientific Reports, 2022 - nature.com
Quantitative MR relaxation parameters vary in the sensitivity to the orientation of the tissue in
the magnetic field. In this study, the orientation dependence of multiple relaxation …

Multi‐parametric MRI characterization of enzymatically degraded articular cartilage

MJ Nissi, EN Salo, V Tiitu, T Liimatainen… - Journal of …, 2016 - Wiley Online Library
Several laboratory and rotating frame quantitative MRI parameters were evaluated and
compared for detection of changes in articular cartilage following selective enzymatic …

MRI relaxation in the presence of fictitious fields correlates with myelin content in normal rat brain

H Hakkarainen, A Sierra, S Mangia… - Magnetic resonance …, 2016 - Wiley Online Library
Purpose Brain myelin plays an important role in normal brain function. Demyelination is
involved in many degenerative brain diseases, thus quantitative imaging of myelin has been …

[HTML][HTML] Infantile status epilepticus disrupts myelin development

P Bencurova, H Laakso, RA Salo, E Paasonen… - Neurobiology of …, 2022 - Elsevier
Temporal lobe epilepsy (TLE) is the most prevalent type of epilepsy in adults; it often starts in
infancy or early childhood. Although TLE is primarily considered to be a grey matter …

[HTML][HTML] Quantification of myocardial infarct area based on TRAFFn relaxation time maps-comparison with cardiovascular magnetic resonance late gadolinium …

E Yla-Herttuala, S Laidinen, H Laakso… - Journal of Cardiovascular …, 2018 - Elsevier
Background Two days after myocardial infarction (MI), the infarct consists mostly on necrotic
tissue, and the myocardium is transformed through granulation tissue to scar in two weeks …

Quantitative susceptibility mapping detects abnormalities in cartilage canals in a goat model of preclinical osteochondritis dissecans

L Wang, MJ Nissi, F Toth, CP Johnson… - Magnetic resonance …, 2017 - Wiley Online Library
Purpose To use quantitative susceptibility mapping (QSM) to investigate changes in
cartilage canals in the distal femur of juvenile goats after their surgical transection. Methods …