Colchicine, a natural and ancient drug still used today, is traditionally considered the staple
therapy for gout and a second-line treatment for pericarditis, as well as a basic part of …

Four major natriuretic peptides have been isolated: atrial natriuretic peptide (ANP), brain
natriuretic peptide (BNP), C‐type natriuretic peptide (CNP), and Dendroaspis‐type …

Spleen tyrosine kinase (Syk) and Bruton's tyrosine kinase (BTK) play critical roles in platelet
physiology, facilitating intracellular immunoreceptor tyrosine-based activation motif (ITAM) …

The cardioprotective mechanisms of colchicine in patients with stable ischemic heart
disease remain uncertain. We tested varying concentrations of colchicine on platelet activity …

Bruton tyrosine kinase (Btk) is not only critical for B cell development and differentiation but
is also involved in the regulation of Toll-like receptor-triggered innate response of …

Cardiovascular disease (CVD) is the primary cause of mortality in cancer survivors. 1 In
particular, radiationassociated cardiovascular disease (RACVD) is the leading cause of …

Colchicine inhibits coronary and cerebrovascular events in patients with coronary artery
disease (CAD), and although known to have anti-inflammatory properties, its mechanisms of …

Store-operated Ca2+ entry (SOCE) is a major pathway for Ca2+ influx in non-excitable cells.
Recent studies favour a conformational coupling mechanism between the endoplasmic …

The microtubule inhibitor and anti-inflammatory agent colchicine is used to treat a range of
conditions involving inflammasome activation in monocytes and neutrophils, and is now …

Ca2+ entry, particularly store-operated Ca2+ entry (SOCE), has been reported to be crucial
for a variety of cellular functions. SOCE is a mechanism regulated by the Ca2+ content of the …