BRCAness, DNA gaps, and gain and loss of PARP inhibitor–induced synthetic lethality

X Li, L Zou - The Journal of clinical investigation, 2024 - jci.org
Mutations in the tumor-suppressor genes BRCA1 and BRCA2 resulting in BRCA1/2
deficiency are frequently identified in breast, ovarian, prostate, pancreatic, and other …

[HTML][HTML] Mechanisms and regulation of replication fork reversal

MB Adolph, D Cortez - DNA repair, 2024 - Elsevier
DNA replication is remarkably accurate with estimates of only a handful of mutations per
human genome per cell division cycle. Replication stress caused by DNA lesions …

ATR inhibition induces synthetic lethality in mismatch repair-deficient cells and augments immunotherapy

M Wang, X Ran, W Leung, A Kawale… - Genes & …, 2023 - genesdev.cshlp.org
The mismatch repair (MMR) deficiency of cancer cells drives mutagenesis and offers a
useful biomarker for immunotherapy. However, many MMR-deficient (MMR-d) tumors do not …

USP1-dependent nucleolytic expansion of PRIMPOL-generated nascent DNA strand discontinuities during replication stress

A Nusawardhana, LM Pale, CM Nicolae… - Nucleic acids …, 2024 - academic.oup.com
DNA replication stress-induced fork arrest represents a significant threat to genomic
integrity. One major mechanism of replication restart involves repriming downstream of the …

Targeting ATR in patients with cancer

NYL Ngoi, PG Pilié, DJ McGrail… - Nature Reviews …, 2024 - nature.com
Pharmacological inhibition of the ataxia telangiectasia and Rad3-related protein
serine/threonine kinase (ATR; also known as FRAP-related protein (FRP1)) has emerged as …

TCAF1 promotes TRPV2-mediated Ca2+ release in response to cytosolic DNA to protect stressed replication forks

L Kong, C Cheng, A Cheruiyot, J Yuan, Y Yang… - Nature …, 2024 - nature.com
The protection of the replication fork structure under stress conditions is essential for
genome maintenance and cancer prevention. A key signaling pathway for fork protection …

FANCM promotes PARP inhibitor resistance by minimizing ssDNA gap formation and counteracting resection inhibition

Z Liu, H Jiang, SY Lee, N Kong, YW Chan - Cell Reports, 2024 - cell.com
Poly (ADP-ribose) polymerase inhibitors (PARPis) exhibit remarkable anticancer activity in
tumors with homologous recombination (HR) gene mutations. However, the role of other …

Regulation, functional impact, and therapeutic targeting of APOBEC3A in cancer

AS Kawale, L Zou - DNA repair, 2024 - Elsevier
Enzymes of the apolipoprotein B mRNA editing catalytic polypeptide like (APOBEC) family
are cytosine deaminases that convert cytosine to uracil in DNA and RNA. Among these …

[HTML][HTML] Exploring RAD18-dependent replication of damaged DNA and discontinuities: A collection of advanced tools

M Mórocz, E Qorri, E Pekker, G Tick, L Haracska - Journal of Biotechnology, 2024 - Elsevier
DNA damage tolerance (DDT) pathways mitigate the effects of DNA damage during
replication by rescuing the replication fork stalled at a DNA lesion or other barriers and also …

PARG inhibitor sensitivity correlates with accumulation of single-stranded DNA gaps in preclinical models of ovarian cancer

R Ravindranathan, O Somuncu, AABA da Costa… - Proceedings of the …, 2024 - pnas.org
Poly (ADP-ribose) glycohydrolase (PARG) is a dePARylating enzyme which promotes DNA
repair by removal of poly (ADP-ribose)(PAR) from PARylated proteins. Loss or inhibition of …