BRCAness, DNA gaps, and gain and loss of PARP inhibitor–induced synthetic lethality
Mutations in the tumor-suppressor genes BRCA1 and BRCA2 resulting in BRCA1/2
deficiency are frequently identified in breast, ovarian, prostate, pancreatic, and other …
deficiency are frequently identified in breast, ovarian, prostate, pancreatic, and other …
[HTML][HTML] Mechanisms and regulation of replication fork reversal
DNA replication is remarkably accurate with estimates of only a handful of mutations per
human genome per cell division cycle. Replication stress caused by DNA lesions …
human genome per cell division cycle. Replication stress caused by DNA lesions …
ATR inhibition induces synthetic lethality in mismatch repair-deficient cells and augments immunotherapy
The mismatch repair (MMR) deficiency of cancer cells drives mutagenesis and offers a
useful biomarker for immunotherapy. However, many MMR-deficient (MMR-d) tumors do not …
useful biomarker for immunotherapy. However, many MMR-deficient (MMR-d) tumors do not …
USP1-dependent nucleolytic expansion of PRIMPOL-generated nascent DNA strand discontinuities during replication stress
A Nusawardhana, LM Pale, CM Nicolae… - Nucleic acids …, 2024 - academic.oup.com
DNA replication stress-induced fork arrest represents a significant threat to genomic
integrity. One major mechanism of replication restart involves repriming downstream of the …
integrity. One major mechanism of replication restart involves repriming downstream of the …
Targeting ATR in patients with cancer
NYL Ngoi, PG Pilié, DJ McGrail… - Nature Reviews …, 2024 - nature.com
Pharmacological inhibition of the ataxia telangiectasia and Rad3-related protein
serine/threonine kinase (ATR; also known as FRAP-related protein (FRP1)) has emerged as …
serine/threonine kinase (ATR; also known as FRAP-related protein (FRP1)) has emerged as …
TCAF1 promotes TRPV2-mediated Ca2+ release in response to cytosolic DNA to protect stressed replication forks
The protection of the replication fork structure under stress conditions is essential for
genome maintenance and cancer prevention. A key signaling pathway for fork protection …
genome maintenance and cancer prevention. A key signaling pathway for fork protection …
FANCM promotes PARP inhibitor resistance by minimizing ssDNA gap formation and counteracting resection inhibition
Poly (ADP-ribose) polymerase inhibitors (PARPis) exhibit remarkable anticancer activity in
tumors with homologous recombination (HR) gene mutations. However, the role of other …
tumors with homologous recombination (HR) gene mutations. However, the role of other …
Regulation, functional impact, and therapeutic targeting of APOBEC3A in cancer
Enzymes of the apolipoprotein B mRNA editing catalytic polypeptide like (APOBEC) family
are cytosine deaminases that convert cytosine to uracil in DNA and RNA. Among these …
are cytosine deaminases that convert cytosine to uracil in DNA and RNA. Among these …
[HTML][HTML] Exploring RAD18-dependent replication of damaged DNA and discontinuities: A collection of advanced tools
DNA damage tolerance (DDT) pathways mitigate the effects of DNA damage during
replication by rescuing the replication fork stalled at a DNA lesion or other barriers and also …
replication by rescuing the replication fork stalled at a DNA lesion or other barriers and also …
PARG inhibitor sensitivity correlates with accumulation of single-stranded DNA gaps in preclinical models of ovarian cancer
Poly (ADP-ribose) glycohydrolase (PARG) is a dePARylating enzyme which promotes DNA
repair by removal of poly (ADP-ribose)(PAR) from PARylated proteins. Loss or inhibition of …
repair by removal of poly (ADP-ribose)(PAR) from PARylated proteins. Loss or inhibition of …