The extracellular matrix (ECM) is one of the major components of tumors that plays multiple
crucial roles, including mechanical support, modulation of the microenvironment, and a …

Cellular mechanotransduction, a critical regulator of numerous biological processes, is the
conversion from mechanical signals to biochemical signals regarding cell activities and …

CD44, a non-kinase cell surface transmembrane glycoprotein, has been widely implicated
as a cancer stem cell (CSC) marker in several cancers. Cells overexpressing CD44 possess …

In recent years, the biological role of changes in physical factors in carcinogenesis and
progression has attracted increasing attention. Matrix stiffness, also known as ECM stress, is …

Simple Summary Cancer metastasis is often associated with a dismal prognosis for the
patient. It is, therefore, crucial to understand the mechanisms behind the cascade of events …

Metastasis is the most complex and deadly event. Tumor-stromal interface is a place where
invasion of tumor cells in the form of single-cell or collective migration occurs, with the latter …

Alteration in the density and composition of extracellular matrix (ECM) occurs in tumors. The
alterations toward both stiffness and degradation are contributed to tumor growth and …

Cancer stem cells (CSCs) are a population of self-renewal cells with high tumorigenic
potency. CSCs can adopt easily with changes in the nearby milieu, and are more resistant to …

Extracellular matrix (ECM) plays a central and dynamic role in the creation of tumor
microenvironment. Herein we discuss the emerging biophysical and biochemical aspects of …

Collagen, an extracellular protein, covers the entire human body and has several important
biological functions in normal physiology. Recently, collagen from non-human sources has …