In late 1993 and early 1994, two distinct lines of research converged on a new tumor
suppressor gene located on human chromosome 9p21. The órst report was of the existence …

The INK4a/ARF locus encodes two physically linked tumor suppressor proteins, p16INK4a
and ARF, which regulate the RB and p53 pathways, respectively. The unusual genomic …

The cell cycle inhibitor p16 INK4a is inactivated in many human tumors and in families with
hereditary melanoma and pancreatic cancer. Tumor-associated alterations in the INK4a …

The INK4a tumor suppressor locus encodes p16 INK4a, an inhibitor of cyclin D-dependent
kinases, and p19 ARF, an alternative reading frame protein that also blocks cell proliferation …

We report a genome-wide association study of melanoma conducted by the GenoMEL
consortium based on 317K tagging SNPs for 1,650 selected cases and 4,336 controls, with …

Background: The major factors individually reported to be associated with an increased
frequency of CDKN2A mutations are increased number of patients with melanoma in a …

Background: Germline mutations in the CDKN2A gene, which encodes two proteins
(p16INK4A and p14ARF), are the most common cause of inherited susceptibility to …

Since its discovery as an inhibitor of cyclin-dependent kinases 4 and 6, the tumor
suppressor p16 has continued to gain widespread importance in cancer. The high frequency …

Malignant melanoma remains one of the fastest growing cancers worldwide. Although the
primary cutaneous melanoma can be managed by surgery, the advanced metastatic …

The INK4A/ARF locus on chromosome 9 is one of the sites mutated most frequently in
human cancer. Two genes comprising overlapping reading frames encoding p16INK4a and …