[HTML][HTML] Cystic fibrosis microbiology: Advances in antimicrobial therapy

V Waters, A Smyth - Journal of cystic fibrosis, 2015 - Elsevier
Much of the improvement in the survival of individuals with cystic fibrosis (CF) is due to
advancements in antimicrobial treatments. New aerosolized antibiotic formulations have …

Structure–activity relationships in β‐defensin peptides

K Taylor, PE Barran, JR Dorin - Peptide Science, 2008 - Wiley Online Library
The β‐defensins comprise a large family of small cationic antimicrobial peptides widely
distributed in plants, mammals and insects. These cysteine rich peptides display …

Garlic Revisited: Antimicrobial Activity of Allicin-Containing Garlic Extracts against Burkholderia cepacia Complex

D Wallock-Richards, CJ Doherty, L Doherty… - PLoS …, 2014 - journals.plos.org
The antimicrobial activities of garlic and other plant alliums are primarily based on allicin, a
thiosulphinate present in crushed garlic bulbs. We set out to determine if pure allicin and …

Dimerization of antimicrobial peptides: a promising strategy to enhance antimicrobial peptide activity

EN Lorenzon, JP Piccoli… - Protein and peptide …, 2019 - ingentaconnect.com
Antimicrobial resistance is a global health problem with strong social and economic impacts.
The development of new antimicrobial agents is considered an urgent challenge. In this …

Emerging concepts promising new horizons for marine biodiscovery and synthetic biology

FJ Reen, JA Gutiérrez-Barranquero, ADW Dobson… - Marine Drugs, 2015 - mdpi.com
The vast oceans of the world, which comprise a huge variety of unique ecosystems, are
emerging as a rich and relatively untapped source of novel bioactive compounds with …

Local inflammation induces complement crosstalk which amplifies the antimicrobial response

J Zhang, J Koh, J Lu, S Thiel, BSH Leong… - PLoS …, 2009 - journals.plos.org
By eliciting inflammatory responses, the human immunosurveillance system notably
combats invading pathogens, during which acute phase proteins (CRP and cytokines) are …

Burkholderia cepacia complex: epithelial cell–pathogen confrontations and potential for therapeutic intervention

S McClean, M Callaghan - Journal of medical …, 2009 - microbiologyresearch.org
Burkholderia cepacia complex (Bcc) is an important and virulent pathogen in cystic fibrosis
patients. The interactions between this pathogen and the host lung epithelium are being …

Analysis and separation of residues important for the chemoattractant and antimicrobial activities of β-defensin 3

K Taylor, DJ Clarke, B McCullough, W Chin… - Journal of Biological …, 2008 - ASBMB
β-Defensins are important in mammalian immunity displaying both antimicrobial and
chemoattractant activities. Three canonical disulfide intramolecular bonds are believed to be …

Effects of dimerization on the structure and biological activity of antimicrobial peptide Ctx-Ha

EN Lorenzón, GF Cespedes, EF Vicente… - Antimicrobial agents …, 2012 - Am Soc Microbiol
It is well known that cationic antimicrobial peptides (cAMPs) are potential microbicidal
agents for the increasing problem of antimicrobial resistance. However, the physicochemical …

Intracellular survival and innate immune evasion of Burkholderia cepacia: Improved understanding of quorum sensing‐controlled virulence factors, biofilm, and …

PS Ganesh, S Vishnupriya, J Vadivelu… - Microbiology and …, 2020 - Wiley Online Library
Burkholderia cepacia complex (Bcc) are opportunistic pathogens implicated with
nosocomial infections, and high rates of morbidity and mortality, especially in individuals …