Drug resistance is a major obstacle in the field of pre-clinical and clinical therapeutics. The
development of novel technologies and targeted therapies have yielded new modalities to …

During viral infection, proper regulation of immune responses is necessary to ensure
successful viral clearance with minimal host tissue damage. Proteasomes play a crucial role …

Neuro-cognitive deficits, neuronal injury, and neurodegeneration are well documented in
alcoholics, yet the underlying mechanisms remain elusive. Oxidative damage of …

The immunoproteasome is a highly efficient proteolytic machinery derived from the
constitutive proteasome and is abundantly expressed in immune cells. The …

Brain microvascular endothelial cells (BMVEC) connected by tight junctions (TJ) form a tight
monolayer at the blood-brain barrier (BBB). We investigated the idea that BBB dysfunction …

Cognitive impairment and neurodegeneration still occur despite highly active antiretroviral
therapy (HAART). While there are many potential reasons for this, there is increasing …

The proteasome is a multi-catalytic protein complex whose primary function is the
degradation of abnormal or foreign proteins. Upon exposure of cells to interferons (IFNs), the …

Methamphetamine (METH) abuse is known to be associated with an inordinate rate of
infections. Although many studies have described the association of METH exposure and …

This article is a review of some of the major epidemiological, behavioral, biological, and
integrative prevention research issues and priorities in the area of HIV_AIDS and alcohol …

The immunoproteasome is a specialized form of proteasome equipped with modified
catalytic subunits that was initially discovered to play a pivotal role in MHC class I antigen …