[HTML][HTML] Genetic diversity of the African malaria vector Anopheles gambiae

Anopheles gambiae 1000 Genomes Consortium - Nature, 2017 - ncbi.nlm.nih.gov
The sustainability of malaria control in Africa is threatened by the rise of insecticide
resistance in Anopheles mosquitoes that transmit the disease 1. To gain a deeper …

Genome variation and population structure among 1142 mosquitoes of the African malaria vector species Anopheles gambiae and Anopheles coluzzii

CS Clarkson, A Miles, NJ Harding, ER Lucas… - Genome …, 2020 - genome.cshlp.org
Mosquito control remains a central pillar of efforts to reduce malaria burden in sub-Saharan
Africa. However, insecticide resistance is entrenched in malaria vector populations, and …

Mapping trends in insecticide resistance phenotypes in African malaria vectors

PA Hancock, CJM Hendriks, JA Tangena, H Gibson… - PLoS …, 2020 - journals.plos.org
Mitigating the threat of insecticide resistance in African malaria vector populations requires
comprehensive information about where resistance occurs, to what degree, and how this …

Evolution of the Insecticide Target Rdl in African Anopheles Is Driven by Interspecific and Interkaryotypic Introgression

X Grau-Bové, S Tomlinson, AO O'Reilly… - Molecular Biology …, 2020 - academic.oup.com
The evolution of insecticide resistance mechanisms in natural populations of Anopheles
malaria vectors is a major public health concern across Africa. Using genome sequence …

Genome-wide divergence among invasive populations of Aedes aegypti in California

Y Lee, H Schmidt, TC Collier, WR Conner… - BMC genomics, 2019 - Springer
Background In the summer of 2013, Aedes aegypti Linnaeus was first detected in three cities
in central California (Clovis, Madera and Menlo Park). It has now been detected in multiple …

Modelling spatiotemporal trends in the frequency of genetic mutations conferring insecticide target-site resistance in African mosquito malaria vector species

PA Hancock, A Lynd, A Wiebe, M Devine, J Essandoh… - BMC biology, 2022 - Springer
Background Resistance in malaria vectors to pyrethroids, the most widely used class of
insecticides for malaria vector control, threatens the continued efficacy of vector control tools …

The potential of gene drives in malaria vector species to control malaria in African environments

PA Hancock, A North, AW Leach, P Winskill… - Nature …, 2024 - nature.com
Gene drives are a promising means of malaria control with the potential to cause sustained
reductions in transmission. In real environments, however, their impacts will depend on local …

Multi-population genomic analysis of malaria parasites indicates local selection and differentiation at the gdv1 locus regulating sexual development

CW Duffy, A Amambua-Ngwa, AD Ahouidi, M Diakite… - Scientific Reports, 2018 - nature.com
Parasites infect hosts in widely varying environments, encountering diverse challenges for
adaptation. To identify malaria parasite genes under locally divergent selection across a …

Conceptual risk assessment of mosquito population modification gene-drive systems to control malaria transmission: preliminary hazards list workshops

A Kormos, G Dimopoulos, E Bier… - … in Bioengineering and …, 2023 - frontiersin.org
The field-testing and eventual adoption of genetically-engineered mosquitoes (GEMs) to
control vector-borne pathogen transmission will require them meeting safety criteria …

Dissecting functional components of reproductive isolation among closely related sympatric species of the Anopheles gambiae complex

M Pombi, P Kengne, G Gimonneau… - Evolutionary …, 2017 - Wiley Online Library
Explaining how and why reproductive isolation evolves and determining which forms of
reproductive isolation have the largest impact on the process of population divergence are …