Tendinopathy

NL Millar, KG Silbernagel, K Thorborg… - Nature reviews Disease …, 2021 - nature.com
Tendinopathy describes a complex multifaceted pathology of the tendon, characterized by
pain, decline in function and reduced exercise tolerance. The most common overuse …

[HTML][HTML] Tendon injury and repair–A perspective on the basic mechanisms of tendon disease and future clinical therapy

JG Snedeker, J Foolen - Acta biomaterialia, 2017 - Elsevier
Tendon is an intricately organized connective tissue that efficiently transfers muscle force to
the bony skeleton. Its structure, function, and physiology reflect the extreme, repetitive …

Inflammatory mechanisms in tendinopathy–towards translation

NL Millar, GAC Murrell, IB McInnes - Nature reviews rheumatology, 2017 - nature.com
Tendinopathy is a multifactorial spectrum of tendon disorders that affects different
anatomical sites and is characterized by activity-related tendon pain. These disorders are …

Tendon and ligament mechanical loading in the pathogenesis of inflammatory arthritis

E Gracey, A Burssens, I Cambré, G Schett… - Nature reviews …, 2020 - nature.com
Mechanical loading is an important factor in musculoskeletal health and disease. Tendons
and ligaments require physiological levels of mechanical loading to develop and maintain …

Tendon injury: from biology to tendon repair

G Nourissat, F Berenbaum, D Duprez - Nature Reviews Rheumatology, 2015 - nature.com
Tendon is a crucial component of the musculoskeletal system. Tendons connect muscle to
bone and transmit forces to produce motion. Chronic and acute tendon injuries are very …

Tendon basic science: Development, repair, regeneration, and healing

N Andarawis‐Puri, EL Flatow… - Journal of Orthopaedic …, 2015 - Wiley Online Library
Tendinopathy and tendon rupture are common and disabling musculoskeletal conditions.
Despite the prevalence of these injuries, a limited number of investigators are conducting …

Therapeutic potential of microRNA in tendon injuries

L Giordano, GD Porta, GM Peretti… - British Medical …, 2020 - academic.oup.com
Introduction The regulatory role of microRNA (miRNA) in several conditions has been
studied, but their function in tendon healing remains elusive. This review summarizes how …

Inflammation activation and resolution in human tendon disease

SG Dakin, FO Martinez, C Yapp, G Wells… - Science translational …, 2015 - science.org
Improved understanding of the role of inflammation in tendon disease is required to facilitate
therapeutic target discovery. We studied supraspinatus tendons from patients experiencing …

Advances toward transformative therapies for tendon diseases

BR Freedman, DJ Mooney, E Weber - Science translational medicine, 2022 - science.org
Approved therapies for tendon diseases have not yet changed the clinical practice of
symptomatic pain treatment and physiotherapy. This review article summarizes advances in …

Tendon development and musculoskeletal assembly: emerging roles for the extracellular matrix

A Subramanian, TF Schilling - Development, 2015 - journals.biologists.com
Tendons and ligaments are extracellular matrix (ECM)-rich structures that interconnect
muscles and bones. Recent work has shown how tendon fibroblasts (tenocytes) interact with …