Evolution of Drug-Resistant Mycobacterium tuberculosis Strains and Their Adaptation to the Human Lung Environment

A Allué-Guardia, JI García, JB Torrelles - Frontiers in Microbiology, 2021 - frontiersin.org
In the last two decades, multi (MDR), extensively (XDR), extremely (XXDR) and total (TDR)
drug-resistant Mycobacterium tuberculosis (M. tb) strains have emerged as a threat to public …

Virulence factors of the Mycobacterium tuberculosis complex

MA Forrellad, LI Klepp, A Gioffré, J Sabio y Garcia… - Virulence, 2013 - Taylor & Francis
The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that
cause tuberculosis in both humans and animals. This illness, still today, remains to be one of …

TubercuList–10 years after

JM Lew, A Kapopoulou, LM Jones, ST Cole - Tuberculosis, 2011 - Elsevier
TubercuList (http://tuberculist. epfl. ch/), the relational database that presents genome-
derived information about H37Rv, the paradigm strain of Mycobacterium tuberculosis, has …

Phylogeny to function: PE/PPE protein evolution and impact on Mycobacterium tuberculosis pathogenicity

S Fishbein, N Van Wyk, RM Warren… - Molecular …, 2015 - Wiley Online Library
The pe/ppe genes represent one of the most intriguing aspects of the M ycobacterium
tuberculosis genome. These genes are especially abundant in pathogenic mycobacteria …

Dynamic antibody responses to the Mycobacterium tuberculosis proteome

S Kunnath-Velayudhan, H Salamon… - Proceedings of the …, 2010 - National Acad Sciences
Considerable effort has been directed toward controlling tuberculosis, which kills almost two
million people yearly. High on the research agenda is the discovery of biomarkers of active …

Comprehensive analysis of exported proteins from Mycobacterium tuberculosis H37Rv

H Målen, FS Berven, KE Fladmark, HG Wiker - Proteomics, 2007 - Wiley Online Library
Proteins secreted by Mycobacterium tuberculosis play an essential role in the pathogenesis
of tuberculosis. The culture filtrates of M. tuberculosis H37Rv made by Sadamu Nagai …

Mycobacterium tuberculosis Protein PE6 (Rv0335c), a Novel TLR4 Agonist, Evokes an Inflammatory Response and Modulates the Cell Death Pathways in …

N Sharma, M Shariq, N Quadir, J Singh… - Frontiers in …, 2021 - frontiersin.org
Mycobacterium tuberculosis (M. tb) is an intracellular pathogen that exploits moonlighting
functions of its proteins to interfere with host cell functions. PE/PPE proteins utilize host …

The PhoP-Dependent ncRNA Mcr7 Modulates the TAT Secretion System in Mycobacterium tuberculosis

L Solans, J Gonzalo-Asensio, C Sala, A Benjak… - PLoS …, 2014 - journals.plos.org
The PhoPR two-component system is essential for virulence in Mycobacterium tuberculosis
where it controls expression of approximately 2% of the genes, including those for the ESX-1 …

M. tuberculosis T cell epitope analysis reveals paucity of antigenic variation and identifies rare variable TB antigens

M Coscolla, R Copin, J Sutherland, F Gehre… - Cell host & …, 2015 - cell.com
Pathogens that evade adaptive immunity typically exhibit antigenic variation. By contrast, it
appears that although the chronic human tuberculosis (TB)-causing pathogen …

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry

DS Kelkar, D Kumar, P Kumar, L Balakrishnan… - Molecular & cellular …, 2011 - ASBMB
The genome sequencing of H37Rv strain of Mycobacterium tuberculosis was completed in
1998 followed by the whole genome sequencing of a clinical isolate, CDC1551 in 2002 …