Vascular endothelial growth factor-A (VEGF) is one of the most important growth factors for
regulation of vascular development and angiogenesis. Since bone is a highly vascularized …

Bone has the unique capacity to heal without the formation of a fibrous scar, likely because
several of the cellular and molecular processes governing bone healing recapitulate the …

The intimate connection, both physical and biochemical, between blood vessels and bone
cells has long been recognized. Genetic, biochemical, and pharmacological studies have …

Over the last decade the identification of mutations in the receptors for fibroblast growth
factors (FGFs) has defined essential roles for FGF signaling in both endochondral and …

The regenerative medicine, a new discipline that merges biological sciences and the
fundamental of engineering to develop biological substitutes, has greatly benefited from …

The lack of a functional vascular supply has, to a large extent, hampered the whole range of
clinical applications of 'successful'laboratory‐based bone tissue engineering strategies. To …

Background: Angiogenesis is likely critical for the process of intramembranous
osteogenesis; however, the developmental relationship between blood vessels and bone …

The working hypothesis of guided bone regeneration (GBR) is that the membrane physically
excludes non-osteogenic tissues from interfering with bone healing. However, the …

Angiogenesis is essential in bone fracture healing for restoring blood flow to the fracture site.
Vascular endothelial growth factor (VEGF) and its receptor have been implicated in this …

BLOOD VESSELS ARE organized in a hierarchical fashion to deliver oxygen, soluble
factors, and various types of cells to all tissues in our body in a carefully regulated manner …