Inhibition of autotaxin alleviates pathological features of hepatic encephalopathy at the level of gut–liver–brain axis: an experimental and bioinformatic study

A Sepehrinezhad, A Shahbazi, MT Joghataei… - Cell death & …, 2023 - nature.com
There is accumulating evidence that the circulatory levels of autotaxin (ATX) and
lysophosphatidic acid (LPA) are increased in patients with severe liver disease. However …

[HTML][HTML] The contributions of bacteria metabolites to the development of hepatic encephalopathy

MC Gilbert, T Setayesh, YJY Wan - Liver research, 2023 - Elsevier
Over 20% of mortality during acute liver failure is associated with the development of hepatic
encephalopathy (HE). Thus, HE is a complication of acute liver failure with a broad spectrum …

Flaxseed Oil (Linum usitatissimum) Prevents Cognitive and Motor Damage in Rats with Hyperammonemia

MF Ocaña-Sánchez, GA Soto-Ojeda… - Nutrients, 2023 - mdpi.com
Hyperammonemia is characterized by the excessive accumulation of ammonia in the body
as a result of the loss of liver detoxification, leading to the development of hepatic …

An Investigation of PS‐b‐PEO Polymersomes for the Oral Treatment and Diagnosis of Hyperammonemia

S Matoori, Y Bao, A Schmidt, EJ Fischer… - Small, 2019 - Wiley Online Library
Ammonia‐scavenging transmembrane pH‐gradient poly (styrene)‐b‐poly (ethylene oxide)
polymersomes are investigated for the oral treatment and diagnosis of hyperammonemia, a …

The effect of rifaximin and lactulose treatments to chronic hepatic encephalopathy rats: An [18F]PBR146 in‐vivo neuroinflammation imaging study

X Kong, S Luo, SY Wu, J Zhang, GF Yang… - Brain and …, 2024 - Wiley Online Library
Introduction Hepatic encephalopathy (HE) is a severe neuropsychiatric complication of liver
diseases characterized by neuroinflammation. The efficacies of nonabsorbable rifaximin …

Bile duct ligation causes opposite impacts on the expression and function of BCRP and P-gp in rat brain partly via affecting membrane expression of ezrin/radixin …

T Wu, Y Sheng, Y Qin, W Kong, M Jin, H Yang… - Acta Pharmacologica …, 2021 - nature.com
Breast cancer resistance protein (BCRP) and P-glycoprotein (P-gp) are co-located at blood–
brain barrier (BBB) cells, preventing their substrates from entering brain. Accumulating …

Cibler le système digestif pour protéger le foie: évaluation de l'efficacité prophylactique et thérapeutique de traitements de l'encéphalopathie hépatique dans un …

G Petrazzo - 2020 - papyrus.bib.umontreal.ca
Introduction. L'encéphalopathie hépatique (HE) est une complication commune mais sévère
des insuffisances hépatiques. La physiopathologie de l'HE provient essentiellement de …

Caracterización de glicosidasas y permeasas fúngicas implicadas en el transporte y metabolismo de azúcares

MF Casa Villegas - 2018 - riunet.upv.es
En aquest treball es van caracteritzar glicosil hidrolases (GHs) i permeases fúngiques
implicades en el metabolisme i transport de sucres, amb dos aplicacions diferents: la …

[PDF][PDF] Investigating poly (styrene)-b-poly (ethylene oxide) polymersomes for the treatment and diagnosis of hyperammonemia

SS Matoori - 2019 - research-collection.ethz.ch
Ammonia is a ubiquitous metabolite in amino acid and protein metabolism. Despite its
important roles in metabolism and pH homeostasis, ammonia needs to be rapidly and …