Three-dimensional multicellular aggregates such as spheroids provide reliable in vitro
substitutes for tissues. Quantitative characterization of spheroids at the cellular level is …

Pluripotent stem cells (PSCs) are important for future regenerative medicine therapies.
However, in the production of PSCs and derivatives, the control of culture-induced …

Image-based assays, such as alkaline phosphatase staining or immunocytochemistry for
pluripotent markers, are common methods used in the stem cell field to assess pluripotency …

A growing body of evidence highlights the importance of the cellular microenvironment as a
regulator of phenotypic and functional cellular responses to perturbations. We have …

Human pluripotent stem cell therapy is a novel approach to cellular therapeutics that can
treat and model multiple diseases, accelerate regenerative medicine, and progress drug …

Pharmaceutical industries have declared their need of metrology in the cellular field, to
improve new drugs developing time and costs by high-content screening technologies. Cell …

Individual cells show variability in their signaling dynamics that often correlates with
phenotypic responses, indicating that cell-to-cell variability is not merely noise but can have …

Research in cell and developmental biology requires the application of three-dimensional
model systems that reproduce the natural environment of cells. Processes in developmental …

Image-based assays, such as alkaline phosphatase staining or immunocytochemistry for
pluripotent markers, are common methods used in the stem cell field to assess pluripotency …

Pluripotent stem cells (PSCs) are important for future regenerative medicine therapies.
However, in the production of PSCs and derivatives, the control of culture-induced …