Glutamate uptake

NC Danbolt - Progress in neurobiology, 2001 - Elsevier
Brain tissue has a remarkable ability to accumulate glutamate. This ability is due to
glutamate transporter proteins present in the plasma membranes of both glial cells and …

[PDF][PDF] Schizophrenia: a disconnection syndrome

KJ Friston, CD Frith - Clin Neurosci, 1995 - fil.ion.ucl.ac.uk
We review the evidence of pathophysiological changes in the prefrontal and temporal
cortices of schizophrenic subjects and of abnormal integration of the physiological dynamics …

Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions …

B Moghaddam, B Adams, A Verma… - Journal of …, 1997 - Soc Neuroscience
Subanesthetic doses of ketamine, a noncompetitive NMDA receptor antagonist, impair
prefrontal cortex (PFC) function in the rat and produce symptoms in humans similar to those …

[图书][B] The cognitive neuropsychology of schizophrenia

CD Frith - 2014 - taylorfrancis.com
Schizophrenic patients have bizarre experiences which reflect a disorder in the contents of
consciousness. For example, patients hear voices talking about them or they are convinced …

The disconnection hypothesis

KJ Friston - Schizophrenia research, 1998 - Elsevier
This article reviews the disconnection hypothesis of schizophrenia and presents a
mechanistic account of how dysfunctional integration among neuronal systems might arise …

Subanesthetic doses of ketamine stimulate psychosis in schizophrenia

AC Lahti, B Koffel, D LaPorte, CA Tamminga - Neuropsychopharmacology, 1995 - Elsevier
We administered ketamine to schizophrenic individuals in a double-blind, placebo-
controlled design using a range of subanesthetic doses (0.1, 0.3, and 0.5 mg/kg) to evaluate …

Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics

S Akbarian, JJ Kim, SG Potkin… - Archives of general …, 1995 - jamanetwork.com
Background: Up-regulation of γ-aminobutyric acid A (GABA A) receptors and decreased
GABA uptake in the cerebral cortex of schizophrenics suggest altered GABAergic …

[HTML][HTML] The limbic system

V Rajmohan, E Mohandas - Indian journal of psychiatry, 2007 - journals.lww.com
The limbic system : Indian Journal of Psychiatry The limbic system : Indian Journal of Psychiatry
Log in or Register Get new issue alertsGet alerts Submit a Manuscript Secondary Logo Journal …

The emerging role of glutamate in the pathophysiology and treatment of schizophrenia

DC Goff, JT Coyle - American Journal of Psychiatry, 2001 - Am Psychiatric Assoc
OBJECTIVE: Research has implicated dysfunction of glutamatergic neurotransmission in the
pathophysiology of schizophrenia. This review evaluates evidence from preclinical and …

Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats

B Moghaddam, BW Adams - Science, 1998 - science.org
Glutamatergic abnormalities have been associated with several psychiatric disorders,
including schizophrenia and addiction. Group II metabotropic glutamate receptors were …