Glutathione-depleting nanomedicines for synergistic cancer therapy

X Cheng, HD Xu, HH Ran, G Liang, FG Wu - ACS nano, 2021 - ACS Publications
Cancer cells frequently exhibit resistance to various molecular and nanoscale drugs, which
inevitably affects the drugs' therapeutic outcomes. Overexpression of glutathione (GSH) has …

Photosensitization and controlled photosensitization with BODIPY dyes

A Turksoy, D Yildiz, EU Akkaya - Coordination Chemistry Reviews, 2019 - Elsevier
Highly versatile BODIPY dyes proved themselves to be very useful as photosensitizers.
These dyes can be derivatized to absorb essentially anywhere in the visible the near IR …

Application of multifunctional BODIPY in photodynamic therapy

W Zhang, A Ahmed, H Cong, S Wang, Y Shen, B Yu - Dyes and Pigments, 2021 - Elsevier
At present, BODIPY and its derivatives are a kind of multifunctional photosensitive organic
dyes, because of their small Stokes shift, strong absorption, narrow absorption and …

Redox status expressed as GSH: GSSG ratio as a marker for oxidative stress in paediatric tumour patients

O Zitka, S Skalickova, J Gumulec… - Oncology …, 2012 - spandidos-publications.com
Oxidative stress causes profound alterations of various biological structures, including
cellular membranes, lipids, proteins and nucleic acids, and it is involved in numerous …

Endocrine resistance in hormone receptor positive breast cancer–from mechanism to therapy

A Rani, J Stebbing, G Giamas, J Murphy - Frontiers in endocrinology, 2019 - frontiersin.org
The importance and role of the estrogen receptor (ER) pathway has been well-documented
in both breast cancer (BC) development and progression. The treatment of choice in women …

Glutathione levels in human tumors

MP Gamcsik, MS Kasibhatla, SD Teeter, OM Colvin - Biomarkers, 2012 - Taylor & Francis
This review summarizes clinical studies in which glutathione was measured in tumor tissue
from patients with brain, breast, gastrointestinal, gynecological, head and neck and lung …

Heparin-functionalized polymeric biomaterials in tissue engineering and drug delivery applications

Y Liang, KL Kiick - Acta biomaterialia, 2014 - Elsevier
Heparin plays an important role in many biological processes via its interaction with various
proteins, and hydrogels and nanoparticles comprising heparin exhibit attractive properties …

Antioxidant activity of sulfur and selenium: a review of reactive oxygen species scavenging, glutathione peroxidase, and metal-binding antioxidant mechanisms

EE Battin, JL Brumaghim - Cell biochemistry and biophysics, 2009 - Springer
It is well known that oxidation caused by reactive oxygen species (ROS) is a major cause of
cellular damage and death and has been implicated in cancer, neurodegenerative, and …

Ultra-fast colorimetric detection of glutathione by magnetic Fe NPs with peroxidase-like activity

L Zhang, J Wang, C Zhao, F Zhou, C Yao… - Sensors and Actuators B …, 2022 - Elsevier
The nanozymes-based sensing platforms have been attracted in recent years due to their
outstanding performances in the practical applications. In this work, the magnetic Fe …

Oxidative stress indexes for diagnosis of health or disease in humans

MA Sánchez-Rodríguez… - Oxidative medicine and …, 2019 - Wiley Online Library
Oxidative stress (OS) is the imbalance between oxidant and antioxidant molecules, in favor
of oxidants, that causes aging and disease. Many studies have been published that …