Mitogen-activated protein kinase (MAPK)-activated protein kinases (MAPKAPKs) are
defined by their exclusive activation by MAPKs. They can be activated by classical and …

During the past decade, an abundance of new evidence highlighted the importance of
inflammation in the development of chronic pathologies such as neurodegeneration, cancer …

Following pathogen infection or tissue damage, the stimulation of pattern recognition
receptors on the cell surface and in the cytoplasm of innate immune cells activates members …

The binding of tumour necrosis factor α (TNFα) to cell surface receptors engages multiple
signal transduction pathways, including three groups of mitogen-activated protein (MAP) …

The mammalian stress-activated families of mitogen-activated protein kinases (MAPKs)
were first elucidated in 1994, and by 2001, substantial progress had been made in …

The mitogen-activated protein kinases (MAPKs) regulate diverse cellular programs by
relaying extracellular signals to intracellular responses. In mammals, there are more than a …

Discoveries made over the past 20 years highlight the importance of mRNA decay as a
means of modulating gene expression and thereby protein production. Up until recently …

Acute stress puts cells at risk, and rapid adaptation is crucial for maximizing cell survival.
Cellular adaptation mechanisms include modification of certain aspects of cell physiology …

Despite the global impact of macrophage activation in vascular disease, the underlying
mechanisms remain obscure. Here we show, with global proteomic analysis of macrophage …

Changes in mRNA stability and translation are critical control points in the regulation of gene
expression, particularly genes encoding growth factors, inflammatory mediators, and proto …