Diabetes mellitus is a severe metabolic disorder, which consistently requires medical care
and self-management to restrict complications, such as obesity, kidney damage and …

Type 1 and type 2 diabetes both result from inadequate production of insulin by the β-cells of
the pancreatic islet. Accordingly, strategies that lead to increased pancreatic β-cell mass, as …

For decades, investigators have made numerous attempts to generate human pancreatic β
cell lines that could be used to advance β cell biology, facilitate drug discovery, and provide …

Diabetic patients exhibit a reduction in β cells, which secrete insulin to help regulate glucose
homeostasis; however, little is known about the factors that regulate proliferation of these …

A biomimetic hydrogel platform was designed to signal encapsulated cells using
immobilized cell–cell communication cues, with a focus on enhancing the survival and …

Severe acute liver failure, even when transient, must be treated by transplantation and
lifelong immune suppression. Treatment could be improved by bioartificial liver (BAL) …

Three novel human insulin-releasing cell lines designated 1.1 B4, 1.4 E7, and 1.1 E7 were
generated by electrofusion of freshly isolated of human pancreatic beta cells and the …

Telomeres serve to camouflage chromosome ends from the DNA damage response
machinery. Telomerase activity is required to maintain telomeres. One consequence of …

The gonadotropin FSH plays a key role in the control of Sertoli cell function. The FSH
molecular mechanism of action is best recognized for its stimulation of the adenylyl …

Macroencapsulation technology has been an attractive topic in the field of treatment for Type
1 diabetes due to mechanical stability, versatility, and retrievability of the macro‐capsule …