The pancreas is made from two distinct components: the exocrine pancreas, a reservoir of
digestive enzymes, and the endocrine islets, the source of the vital metabolic hormone …

Transcription factors regulate gene expression through binding to specific enhancer
sequences. Pancreas/duodenum homeobox protein 1 (PDX1), Neurogenin-3 (NEUROG3) …

Recent breakthroughs in 3-dimensional (3D) organoid cultures for many organ systems
have led to new physiologically complex in vitro models to study human development and …

Biologists have long been intrigued by the possibility that cells can change their identity, a
phenomenon known as cellular plasticity. The discovery that terminally differentiated cells …

Diabetes mellitus, which affects more than 463 million people globally, is caused by the
autoimmune ablation or functional loss of insulin-producing β-cells, and prevalence is …

We have greatly advanced our ability to grow a diverse range of tissue-derived and
pluripotent stem cell–derived gastrointestinal (GI) tissues in vitro. These systems, broadly …

The current study aimed to understand the developmental mechanisms regulating bud tip
progenitor cells in the human fetal lung, which are present during branching …

Gut stem cells are accessible by biopsy and propagate robustly in culture, offering an
invaluable resource for autologous cell therapies. Insulin-producing cells can be induced in …

Human intestinal organoids (HIOs) are a tissue culture model in which small intestine-like
tissue is generated from pluripotent stem cells. By carrying out unsupervised hierarchical …

Diabetes has been a worldwide healthcare problem for many years. Current methods of
treating diabetes are still largely directed at symptoms, aiming to control the manifestations …