Current progress on antioxidants incorporating the pyrazole core

VLM Silva, J Elguero, AMS Silva - European journal of medicinal chemistry, 2018 - Elsevier
The search of new antioxidants, as drugs candidates, is an active field of medicinal
chemistry. The synthesis of compounds with antioxidant potential has increased in recent …

A new insight into the synthesis and biological activities of pyrazole based derivatives

S Mor, M Khatri, R Punia, S Nagoria… - Mini-Reviews in …, 2022 - ingentaconnect.com
This review aims to collate literature work reported by researchers (from 1994 to 2021) to
provide an overview of the available methodologies for the synthesis and diverse …

Design, synthesis, characterization, in vitro screening, molecular docking, 3D-QSAR, and ADME-Tox investigations of novel pyrazole derivatives as antimicrobial …

M Chalkha, M Akhazzane, FZ Moussaid… - New Journal of …, 2022 - pubs.rsc.org
In this work, we report the synthesis of some new pyrazole derivatives via an efficient and
practical procedure. The structures of the obtained compounds were established using …

Chemical composition and in vivo/in silico anti-inflammatory activity of an antioxidant, non-toxic essential oil from Thymus algeriensis Boiss. & Reut.

N Righi, A Deghima, D Ismail, PAR Fernandes… - South African Journal of …, 2023 - Elsevier
Abstract Thymus algeriensis Reut & Boiss is an essential oil-bearing plant widely used in
traditional medicine to treat digestive system disorders and numerous inflammatory …

Pyrazoles containing thiophene, thienopyrimidine and thienotriazolopyrimidine as COX-2 selective inhibitors: Design, synthesis, in vivo anti-inflammatory activity …

MS El-Shoukrofy, HA Abd El Razik, OM AboulWafa… - Bioorganic …, 2019 - Elsevier
New thiophene and annulated thiophene pyrazole hybrids were synthesized and screened
for their in vitro COX-1/COX-2 enzymatic inhibition and in vivo anti-inflammatory activities. All …

Excellent antitumor and antimetastatic activities based on novel coumarin/pyrazole oxime hybrids

H Dai, M Huang, J Qian, J Liu, C Meng, Y Li… - European journal of …, 2019 - Elsevier
A series of hybrids 10a-v based on coumarin/pyrazole oxime have been synthesized, and
exhibit good to excellent antitumor activities. Compound 10n has shown remarkable …

Development of novel bis-pyrazole derivatives as antitumor agents with potent apoptosis induction effects and DNA damage

H Dai, S Ge, J Guo, S Chen, M Huang, J Yang… - European journal of …, 2018 - Elsevier
A series of bis-pyrazole derivatives were designed and synthesized, and their antitumor
effects in vitro and in vivo were investigated. Several compounds displayed good …

Design, synthesis and in silico study of pyridine based 1, 3, 4-oxadiazole embedded hydrazinecarbothioamide derivatives as potent anti-tubercular agent

AN Ambhore, SS Kamble, SN Kadam… - … biology and chemistry, 2019 - Elsevier
Abstract Development of novel, safe and effective drug candidates combating the emerging
drug resistance has remained a major focus in the mainstream of anti-tuberculosis research …

Synthesis, characterization, crystal structure, Hirshfeld surface analysis, antioxidant properties and DFT calculations of a novel pyrazole derivative: ethyl 1-(2, 4 …

S Naveen, K Kumara, AD Kumar, KA Kumar… - Journal of Molecular …, 2021 - Elsevier
An effective route for the direct synthesis of substituted pyrazole through 3+ 2 annulation
method was described.(E)-ethyl 2-benzylidene-3-oxobutanoate was prepared from ethyl …

Synthesis, crystal structure, in-silico ADMET, molecular docking and dynamics simulation studies of thiophene-chalcone analogues

S Nanjundaswamy, MK Hema, CS Karthik… - Journal of Molecular …, 2022 - Elsevier
A novel thiophene-based chalcone derivatives, 3-(pyridin-4-yl)-1-(thiophen-2-yl) prop-2-en-
1-one (Compound 1) and 3-mesityl-1-(thiophen-2-yl) prop-2-en-1-one (Compound 2) were …