Current progress on antioxidants incorporating the pyrazole core
VLM Silva, J Elguero, AMS Silva - European journal of medicinal chemistry, 2018 - Elsevier
The search of new antioxidants, as drugs candidates, is an active field of medicinal
chemistry. The synthesis of compounds with antioxidant potential has increased in recent …
chemistry. The synthesis of compounds with antioxidant potential has increased in recent …
A new insight into the synthesis and biological activities of pyrazole based derivatives
This review aims to collate literature work reported by researchers (from 1994 to 2021) to
provide an overview of the available methodologies for the synthesis and diverse …
provide an overview of the available methodologies for the synthesis and diverse …
Design, synthesis, characterization, in vitro screening, molecular docking, 3D-QSAR, and ADME-Tox investigations of novel pyrazole derivatives as antimicrobial …
M Chalkha, M Akhazzane, FZ Moussaid… - New Journal of …, 2022 - pubs.rsc.org
In this work, we report the synthesis of some new pyrazole derivatives via an efficient and
practical procedure. The structures of the obtained compounds were established using …
practical procedure. The structures of the obtained compounds were established using …
Chemical composition and in vivo/in silico anti-inflammatory activity of an antioxidant, non-toxic essential oil from Thymus algeriensis Boiss. & Reut.
Abstract Thymus algeriensis Reut & Boiss is an essential oil-bearing plant widely used in
traditional medicine to treat digestive system disorders and numerous inflammatory …
traditional medicine to treat digestive system disorders and numerous inflammatory …
Pyrazoles containing thiophene, thienopyrimidine and thienotriazolopyrimidine as COX-2 selective inhibitors: Design, synthesis, in vivo anti-inflammatory activity …
MS El-Shoukrofy, HA Abd El Razik, OM AboulWafa… - Bioorganic …, 2019 - Elsevier
New thiophene and annulated thiophene pyrazole hybrids were synthesized and screened
for their in vitro COX-1/COX-2 enzymatic inhibition and in vivo anti-inflammatory activities. All …
for their in vitro COX-1/COX-2 enzymatic inhibition and in vivo anti-inflammatory activities. All …
Excellent antitumor and antimetastatic activities based on novel coumarin/pyrazole oxime hybrids
H Dai, M Huang, J Qian, J Liu, C Meng, Y Li… - European journal of …, 2019 - Elsevier
A series of hybrids 10a-v based on coumarin/pyrazole oxime have been synthesized, and
exhibit good to excellent antitumor activities. Compound 10n has shown remarkable …
exhibit good to excellent antitumor activities. Compound 10n has shown remarkable …
Development of novel bis-pyrazole derivatives as antitumor agents with potent apoptosis induction effects and DNA damage
H Dai, S Ge, J Guo, S Chen, M Huang, J Yang… - European journal of …, 2018 - Elsevier
A series of bis-pyrazole derivatives were designed and synthesized, and their antitumor
effects in vitro and in vivo were investigated. Several compounds displayed good …
effects in vitro and in vivo were investigated. Several compounds displayed good …
Design, synthesis and in silico study of pyridine based 1, 3, 4-oxadiazole embedded hydrazinecarbothioamide derivatives as potent anti-tubercular agent
AN Ambhore, SS Kamble, SN Kadam… - … biology and chemistry, 2019 - Elsevier
Abstract Development of novel, safe and effective drug candidates combating the emerging
drug resistance has remained a major focus in the mainstream of anti-tuberculosis research …
drug resistance has remained a major focus in the mainstream of anti-tuberculosis research …
Synthesis, characterization, crystal structure, Hirshfeld surface analysis, antioxidant properties and DFT calculations of a novel pyrazole derivative: ethyl 1-(2, 4 …
An effective route for the direct synthesis of substituted pyrazole through 3+ 2 annulation
method was described.(E)-ethyl 2-benzylidene-3-oxobutanoate was prepared from ethyl …
method was described.(E)-ethyl 2-benzylidene-3-oxobutanoate was prepared from ethyl …
Synthesis, crystal structure, in-silico ADMET, molecular docking and dynamics simulation studies of thiophene-chalcone analogues
S Nanjundaswamy, MK Hema, CS Karthik… - Journal of Molecular …, 2022 - Elsevier
A novel thiophene-based chalcone derivatives, 3-(pyridin-4-yl)-1-(thiophen-2-yl) prop-2-en-
1-one (Compound 1) and 3-mesityl-1-(thiophen-2-yl) prop-2-en-1-one (Compound 2) were …
1-one (Compound 1) and 3-mesityl-1-(thiophen-2-yl) prop-2-en-1-one (Compound 2) were …