Drug-metabolizing enzymes (DMEs) and transporters play pivotal roles in the disposition
and detoxification of numerous foreign and endogenous chemicals. To accommodate …

Glucuronidation represents a major pathway which enhances the elimination of many
lipophilic xenobiotics and endobiotics to more water-soluble compounds. The UDP …

Transcriptional activation of the human CYP1A1 gene (coding for cytochrome P450 1A1) is
mediated by the aryl hydrocarbon receptor (AhR). In the present study we have examined …

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor with important
roles in metabolic adaptation, normal physiology and dioxin toxicology. Metabolic …

NAD (P) H: quinone oxidoreductase 1 (NQO1) is a key enzyme involved in defence against
reactive forms of oxygen and inhibition of neoplasia. Under conditions of oxidative stress …

Enzymes that catalyze the biotransformation of drugs and xenobiotics are generally referred
to as drug‐metabolizing e nzymes (DMEs). DMEs can be classified into two main groups …

Chemotherapy is one of the three most common treatment modalities for cancer. However,
its efficacy is limited by multidrug resistant cancer cells. Drug metabolizing enzymes (DMEs) …

Ferritin is a ubiquitous intracellular iron storage protein that consists of 24 subunits of the H
and L type. The ability to sequester iron from participation in oxygen free radical formation is …

Cells in vivo are constantly exposed to reactive oxygen species (ROS) generated
endogenously and exogenously. To defend against the deleterious consequences of ROS …

Comparative approaches were used to identify human, mouse and rat dioxin response
elements (DREs) in genomic sequences unambiguously assigned to a nucleotide RefSeq …