Genome-wide association studies
Genome-wide association studies (GWAS) test hundreds of thousands of genetic variants
across many genomes to find those statistically associated with a specific trait or disease …
across many genomes to find those statistically associated with a specific trait or disease …
Using genetic data to strengthen causal inference in observational research
Causal inference is essential across the biomedical, behavioural and social sciences. By
progressing from confounded statistical associations to evidence of causal relationships …
progressing from confounded statistical associations to evidence of causal relationships …
Genetic analysis of social-class mobility in five longitudinal studies
A summary genetic measure, called a “polygenic score,” derived from a genome-wide
association study (GWAS) of education can modestly predict a person's educational and …
association study (GWAS) of education can modestly predict a person's educational and …
[HTML][HTML] Comparing within-and between-family polygenic score prediction
Polygenic scores are a popular tool for prediction of complex traits. However, prediction
estimates in samples of unrelated participants can include effects of population stratification …
estimates in samples of unrelated participants can include effects of population stratification …
Using genetics for social science
KP Harden, PD Koellinger - Nature human behaviour, 2020 - nature.com
Social science genetics is concerned with understanding whether, how and why genetic
differences between human beings are linked to differences in behaviours and …
differences between human beings are linked to differences in behaviours and …
Polygenic scores: prediction versus explanation
R Plomin, S Von Stumm - Molecular psychiatry, 2022 - nature.com
During the past decade, polygenic scores have become a fast-growing area of research in
the behavioural sciences. The ability to directly assess people's genetic propensities has …
the behavioural sciences. The ability to directly assess people's genetic propensities has …
Parental characteristics and offspring mental health and related outcomes: A systematic review of genetically informative literature
Various parental characteristics, including psychiatric disorders and parenting behaviours,
are associated with offspring mental health and related outcomes in observational studies …
are associated with offspring mental health and related outcomes in observational studies …
More than nature and nurture, indirect genetic effects on children's academic achievement are consequences of dynastic social processes
Abstract Families transmit genes and environments across generations. When parents'
genetics affect their children's environments, these two modes of inheritance can produce an …
genetics affect their children's environments, these two modes of inheritance can produce an …
The Netherlands twin register: longitudinal research based on twin and twin-family designs
L Ligthart, CEM van Beijsterveldt… - Twin Research and …, 2019 - cambridge.org
The Netherlands Twin Register (NTR) is a national register in which twins, multiples and
their parents, siblings, spouses and other family members participate. Here we describe the …
their parents, siblings, spouses and other family members participate. Here we describe the …
Twin studies to GWAS: there and back again
The field of human behavioral genetics has come full circle. It began by using twin/family
studies to estimate the relative importance of genetic and environmental influences. As large …
studies to estimate the relative importance of genetic and environmental influences. As large …