Genome-wide association studies

E Uffelmann, QQ Huang, NS Munung… - Nature Reviews …, 2021 - nature.com
Genome-wide association studies (GWAS) test hundreds of thousands of genetic variants
across many genomes to find those statistically associated with a specific trait or disease …

Using genetic data to strengthen causal inference in observational research

JB Pingault, PF O'reilly, T Schoeler… - Nature Reviews …, 2018 - nature.com
Causal inference is essential across the biomedical, behavioural and social sciences. By
progressing from confounded statistical associations to evidence of causal relationships …

Genetic analysis of social-class mobility in five longitudinal studies

DW Belsky, BW Domingue, R Wedow… - Proceedings of the …, 2018 - National Acad Sciences
A summary genetic measure, called a “polygenic score,” derived from a genome-wide
association study (GWAS) of education can modestly predict a person's educational and …

[HTML][HTML] Comparing within-and between-family polygenic score prediction

S Selzam, SJ Ritchie, JB Pingault, CA Reynolds… - The American Journal of …, 2019 - cell.com
Polygenic scores are a popular tool for prediction of complex traits. However, prediction
estimates in samples of unrelated participants can include effects of population stratification …

Using genetics for social science

KP Harden, PD Koellinger - Nature human behaviour, 2020 - nature.com
Social science genetics is concerned with understanding whether, how and why genetic
differences between human beings are linked to differences in behaviours and …

Polygenic scores: prediction versus explanation

R Plomin, S Von Stumm - Molecular psychiatry, 2022 - nature.com
During the past decade, polygenic scores have become a fast-growing area of research in
the behavioural sciences. The ability to directly assess people's genetic propensities has …

Parental characteristics and offspring mental health and related outcomes: A systematic review of genetically informative literature

ES Jami, AR Hammerschlag, M Bartels… - Translational …, 2021 - nature.com
Various parental characteristics, including psychiatric disorders and parenting behaviours,
are associated with offspring mental health and related outcomes in observational studies …

More than nature and nurture, indirect genetic effects on children's academic achievement are consequences of dynastic social processes

MG Nivard, DW Belsky, KP Harden, T Baier… - Nature Human …, 2024 - nature.com
Abstract Families transmit genes and environments across generations. When parents'
genetics affect their children's environments, these two modes of inheritance can produce an …

The Netherlands twin register: longitudinal research based on twin and twin-family designs

L Ligthart, CEM van Beijsterveldt… - Twin Research and …, 2019 - cambridge.org
The Netherlands Twin Register (NTR) is a national register in which twins, multiples and
their parents, siblings, spouses and other family members participate. Here we describe the …

Twin studies to GWAS: there and back again

NP Friedman, MT Banich, MC Keller - Trends in cognitive sciences, 2021 - cell.com
The field of human behavioral genetics has come full circle. It began by using twin/family
studies to estimate the relative importance of genetic and environmental influences. As large …