The bone matrix plays an indispensable role in the human body, and its unique
biomechanical and mechanobiological properties have received much attention. The bone …

Wnt signaling occurs through evolutionarily conserved pathways that affect cellular
proliferation and fate decisions during development and tissue maintenance. Alterations in …

Bone is one of the most common sites of tumor metastases. During the last step of bone
metastasis, cancer cells colonize and disrupt the bone matrix, which is maintained mainly by …

Background: Bone is a frequent site of metastases from breast cancer, but existing
therapeutic options are not satisfactory. Although osteoblasts have active roles in cancer …

Rationale: The progression of cancer cells depends on the soil and building an inhibitory
soil might be a therapeutic option. We previously created tumor-suppressive secretomes by …

Background: Advanced breast cancer frequently metastasizes to bone, but inhibiting tumor
progression in chemotherapy may occasionally enhance tumorigenesis. Here, we employed …

Prostate cancer (PCa) is an increasingly prevalent health problem in the developed world.
Effective treatment options exist for localized PCa, but metastatic PCa has fewer treatment …

Osteosarcoma (OS) is the common primary bone cancer that affects mostly children and
young adults. To augment the standard-of-care chemotherapy, we examined the possibility …

Background: During a developmental process, embryos employ varying tactics to remove
unwanted cells. Using a procedure analogous to some of the embryonic cells, we generated …

Cancer cells tend to develop resistance to chemotherapy and enhance aggressiveness. A
counterintuitive approach is to tame aggressiveness by an agent that acts opposite to …