Systemic metabolism has to be constantly adjusted to the variance of food intake and even
be prepared for anticipated changes in nutrient availability. Therefore, the brain integrates …

Engineered neurobiological tools for the manipulation of cellular activity, such as
chemogenetics and optogenetics, have become a cornerstone of modern neuroscience …

Studies have found that intermittent fasting (IF) can prevent diabetes, cancer, heart disease,
and neuropathy, while in humans it has helped to alleviate metabolic syndrome, asthma …

Liver mitochondria play a central role in metabolic adaptations to changing nutritional states,
yet their dynamic regulation upon anticipated changes in nutrient availability has remained …

Hypothalamic mTORC1 signaling is involved in nutrient sensing. Neurons that express the
agouti-related protein (AgRP) are activated by food restriction and integrate interoceptive …

Diet and circadian rhythms have been found to have a profound impact on health, disease,
and aging. Skipping breakfast, eating late, and overeating have adverse effects on the …

Abstract Agouti-related peptide (AgRP)-expressing and proopiomelanocortin (POMC)-
expressing neurons reciprocally regulate food intake. Here, we combine non-interacting …

Activation of the hypothalamus-pituitary-adrenal gland (HPA) axis confers adaptations to
homeostatic perturbations including food scarcity. A comprehensive new study by Douglass …

Background High-protein diets are often enriched with branched-chain amino acids
(BCAAs) known to enhance protein synthesis and provide numerous physiological benefits …

For centuries, increasingly sophisticated methods and approaches have been brought to
bear to promote weight loss. Second, only to the Holy Grail of research on aging, the idea of …