Virus-specific CD8+ T cells that differentiate in the context of resolved versus persisting
infections exhibit divergent phenotypic and functional characteristics, which suggests that …

Adaptive immune responses rely on the proliferation of T lymphocytes able to recognize and
eliminate pathogens. The magnitude and duration of the expansion of activated T cell clones …

CD8+ T cells that respond to chronic viral infections or cancer are characterized by the
expression of inhibitory receptors such as programmed cell death protein 1 (PD-1) and by …

Clonal expansion of cells with somatically diversified receptors and their long-term
maintenance as memory cells is a hallmark of adaptive immunity. Here, we studied …

Clonal expansion is a core aspect of T cell immunity. However, little is known with respect to
the relationship between replicative history and the formation of distinct CD8+ memory T cell …

Failure of adoptive T-cell therapies in patients with cancer is linked to limited T-cell
expansion and persistence, even in memory-prone 41BB-(BBz)–based chimeric antigen …

Upon viral infection, natural killer (NK) cells expressing certain germline-encoded receptors
are selected, expanded, and maintained in an adaptive-like manner. Currently, these are …

Microanatomical organization of innate immune cells within lymph nodes (LNs) is critical for
the generation of adaptive responses. In particular, steady-state LN-resident dendritic cells …

Neuromyelitis optica is a paradigmatic autoimmune disease of the central nervous system,
in which the water-channel protein AQP4 is the target antigen. The immunopathology in …

Engagement of the inhibitory T cell receptor programmed cell death protein 1 (PD-1)
associates with dysfunctional states of pathogen-or tumor-specific T cells. Accordingly …