N TRK gene fusions involving either NTRK1, NTRK2 or NTRK3 (encoding the neurotrophin
receptors TRKA, TRKB and TRKC, respectively) are oncogenic drivers of various adult and …

Understanding the mechanisms that underlie learning is one of the most fascinating and
central aims of neurobiological research. Hippocampal long-term potentiation (LTP) is …

Peripheral nerves injuries result in paralysis, anesthesia and lack of autonomic control of the
affected body areas. After injury, axons distal to the lesion are disconnected from the …

Brain-derived neurotrophic factor (BDNF) is a small dimeric protein, structurally related to
nerve growth factor, which is abundantly and widely expressed in the adult mammalian …

Background Major efforts have been made in the last decade to develop and improve
therapies for proximal spinal muscular atrophy (SMA). The introduction of …

Eph receptor tyrosine kinases and their cell-surface-bound ligands, the ephrins, regulate
axon guidance and bundling in the developing brain, control cell migration and adhesion …

Accumulating evidence indicates that the Trk family of tyrosine protein kinase receptors, Trk
(also known as TrkA), TrkB, and TrkC, are responsible for mediating the trophic effects of the …

Brain-derived neurotrophic factor (BDNF) is a critical growth factor involved in the maturation
of the CNS, including neuronal morphology and synapse refinement. Herein, we …

Signaling pathways that mediate the normal functions of growth factors are commonly
subverted in cancer. Oncogenes identified by a variety of approaches have been shown to …

The decline observed during aging involves multiple factors that influence several systems.
It is the case for learning and memory processes which are severely reduced with aging. It is …