Alternative polyadenylation (APA) is emerging as a widespread mechanism used to control
gene expression. Like alternative splicing, usage of alternative poly (A) sites allows a single …

The untranslated regions (UTRs) at the 3'end of mRNA transcripts contain important
sequences that influence the fate of mRNA and thus proteosynthesis. In this review, we …

ABSTRACT Messenger RNA (mRNA) 3′ end formation is a nuclear process through which
all eukaryotic primary transcripts are endonucleolytically cleaved and most of them acquire a …

Translation of localized mRNA is a fast and efficient way of reacting to extracellular stimuli
with the added benefit of providing spatial resolution to the cellular response. The efficacy of …

Termination of transcription by RNA polymerase II requires two distinct processes: The
formation of a defined 3′ end of the transcribed RNA, as well as the disengagement of RNA …

Regulation of gene expression by RNA processing mechanisms is now understood to be an
important level of control in mammalian cells. Regulation at the level of RNA transcription …

Simple Summary Triple-Negative breast cancer (TNBC) is the most aggressive form of
breast cancer in women. Targeted therapies for the treatment of this disease are severely …

Stresses from various environmental challenges continually confront plants, and their
responses are important for growth and survival. One molecular response to such …

Alternative polyadenylation (APA) is an important regulatory mechanism of gene functions in
many biological processes. However, the extent of 3′ UTR variation and the function of …

Background Polyadenylation, an essential step in eukaryotic gene expression, requires both
cis-elements and a plethora of trans-acting polyadenylation factors. The polyadenylation …