The C. elegans insulin/IGF-1 signaling (IIS) pathway connects nutrient levels to metabolism,
growth, development, longevity, and behavior. This fundamental pathway is regulated by …

How animals establish and pattern the primary body axis is one of the most fundamental
problems in biology. Data from diverse deuterostomes (frog, fish, mouse, and amphioxus) …

This review focuses on the tissue/planar cell polarity (PCP) pathway and its role in
generating spatial patterns in vertebrates. Current evidence suggests that PCP integrates …

The Wnt family of secreted proteins plays a crucial role in nervous system wiring. Wnts
regulate neuronal positioning, polarization, axon and dendrite development, and …

Wnt proteins are secreted signaling molecules that play a central role in development and
adult tissue homeostasis. We have previously shown that Wnt signaling requires retromer …

The assembly of specific synaptic connections during development of the nervous system
represents a remarkable example of cellular recognition and differentiation. Neurons employ …

Secreted Wnt proteins influence neural connectivity by regulating axon guidance, dendritic
morphogenesis and synapse formation. We report a new role for Wnt and Frizzled proteins …

While endocytosis can regulate morphogen distribution, its precise role in shaping these
gradients is unclear. Even more enigmatic is the role of retromer, a complex that shuttles …

Nervous system function is mediated by a precisely patterned network of synaptic
connections. While several cell-adhesion and secreted molecules promote the assembly of …

Secreted proteins of the Wnt family affect axon guidance, asymmetric cell division, and cell
fate. We show here that C. elegans Wnts acting through Frizzled receptors can shape axon …