The role of natural products in drug discovery and development against neglected tropical diseases

PM Cheuka, G Mayoka, P Mutai, K Chibale - Molecules, 2016 - mdpi.com
Endemic in 149 tropical and subtropical countries, neglected tropical diseases (NTDs) affect
more than 1 billion people annually, including 875 million children in developing …

Alkaloids in contemporary drug discovery to meet global disease needs

S Daley, GA Cordell - Molecules, 2021 - mdpi.com
An overview is presented of the well-established role of alkaloids in drug discovery, the
application of more sustainable chemicals, and biological approaches, and the …

Antischistosomal agents: state of art and perspectives

EM Lago, RP Xavier, TR Teixeira, LM Silva… - Future Medicinal …, 2018 - Taylor & Francis
Praziquantel has remained the drug of choice for schistosomiasis chemotherapy for almost
40 years. The pressing need to develop a new antischistosomal drug may necessitate …

Computational quantum chemistry, molecular docking, and ADMET predictions of imidazole alkaloids of Pilocarpus microphyllus with schistosomicidal properties

JA Rocha, NCS Rego, BTS Carvalho, FI Silva… - PloS one, 2018 - journals.plos.org
Schistosomiasis affects million people and its control is widely dependent on a single drug,
praziquantel. Computational chemistry has led to the development of new tools that predict …

Antiparasitic activity of piplartine (piperlongumine) in a mouse model of schistosomiasis

AC Mengarda, PS Mendonca, CS Morais, RM Cogo… - Acta tropica, 2020 - Elsevier
Schistosomiasis is one of the most important parasitic infections in terms of its negative
effects on public health and economics. Since praziquantel is currently the only drug …

Antiparasitic activity of nerolidol in a mouse model of schistosomiasis

MP Silva, RN de Oliveira, AC Mengarda… - International Journal of …, 2017 - Elsevier
Schistosomiasis is a major public health problem worldwide, especially in poor
communities. Since praziquantel is currently the only drug available to treat schistosomiasis …

Licarin A, a neolignan isolated from Nectandra oppositifolia Nees & Mart. (Lauraceae), exhibited moderate preclinical efficacy against Schistosoma mansoni …

AC Mengarda, MP Silva, ME Cirino… - Phytotherapy …, 2021 - Wiley Online Library
Schistosomiasis is a widespread human parasitic disease currently affecting over 200
million people, particularly in poor communities. Chemotherapy for schistosomiasis relies …

Phenotypic screening of nonsteroidal anti-inflammatory drugs identified mefenamic acid as a drug for the treatment of schistosomiasis

EM Lago, MP Silva, TG Queiroz, SF Mazloum… - …, 2019 - thelancet.com
Background Treatment and control of schistosomiasis, one of the most insidious and serious
parasitic diseases, depend almost entirely on a single drug, praziquantel. Since the funding …

Promethazine Exhibits Antiparasitic Properties In Vitro and Reduces Worm Burden, Egg Production, Hepatomegaly, and Splenomegaly in a Schistosomiasis Animal …

DB Roquini, RM Cogo, AC Mengarda… - Antimicrobial agents …, 2019 - Am Soc Microbiol
The treatment and control of schistosomiasis, a neglected disease that affects more than 200
million people worldwide, rely on the use of a single drug, praziquantel. A vaccine has yet to …

Neolignans isolated from Saururus cernuus L. (Saururaceae) exhibit efficacy against Schistosoma mansoni

JR Brito, P Wilairatana, DB Roquini, BC Parra… - Scientific Reports, 2022 - nature.com
Schistosomiasis, a parasitic disease caused by the blood fluke of the genus Schistosoma,
affects over 230 million people, especially in developing countries. Despite the significant …