Phosphoinositides are signalling lipids derived from phosphatidylinositol, a ubiquitous
phospholipid in the cytoplasmic leaflet of eukaryotic membranes. Initially discovered for their …

Clathrin-mediated endocytosis is a key process in vesicular trafficking that transports a wide
range of cargo molecules from the cell surface to the interior. Clathrin-mediated endocytosis …

Summary VAP (VAPA and VAPB) is an evolutionarily conserved endoplasmic reticulum (ER)-
anchored protein that helps generate tethers between the ER and other membranes through …

Polyphosphoinositides (PPIs) are essential phospholipids located in the cytoplasmic leaflet
of eukaryotic cell membranes. Despite contributing only a small fraction to the bulk of cellular …

Phosphoinositides are lipids involved in the vesicular transport of proteins and lipids
between the different compartments of eukaryotic cells. They act by recruiting and/or …

Most functions of eukaryotic cells are controlled by cellular membranes, which are not static
entities but undergo frequent budding, fission, fusion, and sculpting reactions collectively …

Phosphoinositides (PIs) are phospholipids that perform crucial cell functions, ranging from
cell migration and signaling to membrane trafficking, by serving as signposts of …

Clathrin-mediated endocytosis is an essential cellular mechanism by which all eukaryotic
cells regulate their plasma membrane composition to control processes ranging from cell …

Phosphoinositides (PtdIns) control fundamental cell processes, and inherited defects of
PtdIns kinases or phosphatases cause severe human diseases, including Lowe syndrome …

Neurodegenerative diseases are amongst the most devastating of human disorders. New
technologies have led to a rapid increase in the identification of disease-related genes with …