Spatial-ID: a cell typing method for spatially resolved transcriptomics via transfer learning and spatial embedding

R Shen, L Liu, Z Wu, Y Zhang, Z Yuan, J Guo… - Nature …, 2022 - nature.com
Spatially resolved transcriptomics provides the opportunity to investigate the gene
expression profiles and the spatial context of cells in naive state, but at low transcript …

Pharmacological targeting of glutamatergic neurons within the brainstem for weight reduction

M Schneeberger, NL Brice, K Pellegrino, L Parolari… - Nature …, 2022 - nature.com
Food intake and body weight are tightly regulated by neurons within specific brain regions,
including the brainstem, where acute activation of dorsal raphe nucleus (DRN) …

Aggression modulator: Understanding the multifaceted role of the dorsal raphe nucleus

K Mitsui, A Takahashi - BioEssays, 2024 - Wiley Online Library
Aggressive behavior is instinctively driven behavior that helps animals to survive and
reproduce and is closely related to multiple behavioral and physiological processes. The …

[HTML][HTML] Dorsal raphe serotonergic neurons suppress feeding through redundant forebrain circuits

I Aklan, N Sayar-Atasoy, F Deng, H Kim, Y Yavuz… - Molecular …, 2023 - Elsevier
Objective Serotonin (5HT) is a well-known anorexigenic molecule, and 5HT neurons of
dorsal raphe nucleus (DRN) have been implicated in suppression of feeding; however, the …

Phase-shifting the circadian glucocorticoid profile induces disordered feeding behaviour by dysregulating hypothalamic neuropeptide gene expression

M Yoshimura, BP Flynn, YM Kershaw, Z Zhao… - Communications …, 2023 - nature.com
Here we demonstrate, in rodents, how the timing of feeding behaviour becomes disordered
when circulating glucocorticoid rhythms are dissociated from lighting cues; a phenomenon …

Serotonergic regulation of appetite and sodium appetite

Y Shin, S Kim, JW Sohn - Journal of Neuroendocrinology, 2023 - Wiley Online Library
Serotonin is a neurotransmitter that is synthesized and released from the brainstem raphe
nuclei to affect many brain functions. It is well known that the activity of raphe serotonergic …

A light-responsive neural circuit suppresses feeding

H Liu, N Qu, NV Gonzalez, MA Palma, H Chen… - Journal of …, 2024 - jneurosci.org
Light plays an essential role in a variety of physiological processes, including vision, mood,
and glucose homeostasis. However, the intricate relationship between light and an animal's …

[HTML][HTML] Dorsal raphe neurons signal integrated value during multi-attribute decision-making

YY Feng, ES Bromberg-Martin, IE Monosov - bioRxiv, 2023 - ncbi.nlm.nih.gov
The dorsal raphe nucleus (DRN) is implicated in psychiatric disorders that feature impaired
sensitivity to reward amount, impulsivity when facing reward delays, and risk-seeking when …

General and anxiety-linked influences of acute serotonin reuptake inhibition on neural responses associated with attended visceral sensation

JJA Livermore, LI Skora, K Adamatzky… - Translational …, 2024 - nature.com
Ordinary sensations from inside the body are important causes and consequences of our
affective states and behaviour, yet the roles of neurotransmitters in interoceptive processing …

Dorsal raphe neurons integrate the values of reward amount, delay, and uncertainty in multi-attribute decision-making

YY Feng, ES Bromberg-Martin, IE Monosov - Cell Reports, 2024 - cell.com
The dorsal raphe nucleus (DRN) is implicated in psychiatric disorders that feature impaired
sensitivity to reward amount, impulsivity when facing reward delays, and risk-seeking when …