Spatial-ID: a cell typing method for spatially resolved transcriptomics via transfer learning and spatial embedding
R Shen, L Liu, Z Wu, Y Zhang, Z Yuan, J Guo… - Nature …, 2022 - nature.com
Spatially resolved transcriptomics provides the opportunity to investigate the gene
expression profiles and the spatial context of cells in naive state, but at low transcript …
expression profiles and the spatial context of cells in naive state, but at low transcript …
Pharmacological targeting of glutamatergic neurons within the brainstem for weight reduction
Food intake and body weight are tightly regulated by neurons within specific brain regions,
including the brainstem, where acute activation of dorsal raphe nucleus (DRN) …
including the brainstem, where acute activation of dorsal raphe nucleus (DRN) …
Aggression modulator: Understanding the multifaceted role of the dorsal raphe nucleus
K Mitsui, A Takahashi - BioEssays, 2024 - Wiley Online Library
Aggressive behavior is instinctively driven behavior that helps animals to survive and
reproduce and is closely related to multiple behavioral and physiological processes. The …
reproduce and is closely related to multiple behavioral and physiological processes. The …
[HTML][HTML] Dorsal raphe serotonergic neurons suppress feeding through redundant forebrain circuits
Objective Serotonin (5HT) is a well-known anorexigenic molecule, and 5HT neurons of
dorsal raphe nucleus (DRN) have been implicated in suppression of feeding; however, the …
dorsal raphe nucleus (DRN) have been implicated in suppression of feeding; however, the …
Phase-shifting the circadian glucocorticoid profile induces disordered feeding behaviour by dysregulating hypothalamic neuropeptide gene expression
M Yoshimura, BP Flynn, YM Kershaw, Z Zhao… - Communications …, 2023 - nature.com
Here we demonstrate, in rodents, how the timing of feeding behaviour becomes disordered
when circulating glucocorticoid rhythms are dissociated from lighting cues; a phenomenon …
when circulating glucocorticoid rhythms are dissociated from lighting cues; a phenomenon …
Serotonergic regulation of appetite and sodium appetite
Y Shin, S Kim, JW Sohn - Journal of Neuroendocrinology, 2023 - Wiley Online Library
Serotonin is a neurotransmitter that is synthesized and released from the brainstem raphe
nuclei to affect many brain functions. It is well known that the activity of raphe serotonergic …
nuclei to affect many brain functions. It is well known that the activity of raphe serotonergic …
A light-responsive neural circuit suppresses feeding
H Liu, N Qu, NV Gonzalez, MA Palma, H Chen… - Journal of …, 2024 - jneurosci.org
Light plays an essential role in a variety of physiological processes, including vision, mood,
and glucose homeostasis. However, the intricate relationship between light and an animal's …
and glucose homeostasis. However, the intricate relationship between light and an animal's …
[HTML][HTML] Dorsal raphe neurons signal integrated value during multi-attribute decision-making
YY Feng, ES Bromberg-Martin, IE Monosov - bioRxiv, 2023 - ncbi.nlm.nih.gov
The dorsal raphe nucleus (DRN) is implicated in psychiatric disorders that feature impaired
sensitivity to reward amount, impulsivity when facing reward delays, and risk-seeking when …
sensitivity to reward amount, impulsivity when facing reward delays, and risk-seeking when …
General and anxiety-linked influences of acute serotonin reuptake inhibition on neural responses associated with attended visceral sensation
JJA Livermore, LI Skora, K Adamatzky… - Translational …, 2024 - nature.com
Ordinary sensations from inside the body are important causes and consequences of our
affective states and behaviour, yet the roles of neurotransmitters in interoceptive processing …
affective states and behaviour, yet the roles of neurotransmitters in interoceptive processing …
Dorsal raphe neurons integrate the values of reward amount, delay, and uncertainty in multi-attribute decision-making
YY Feng, ES Bromberg-Martin, IE Monosov - Cell Reports, 2024 - cell.com
The dorsal raphe nucleus (DRN) is implicated in psychiatric disorders that feature impaired
sensitivity to reward amount, impulsivity when facing reward delays, and risk-seeking when …
sensitivity to reward amount, impulsivity when facing reward delays, and risk-seeking when …