Considerations for setting occupational exposure limits for novel pharmaceutical modalities

JC Graham, J Hillegass, G Schulze - Regulatory Toxicology and …, 2020 - Elsevier
In order to develop new and effective medicines, pharmaceutical companies must be
modality agnostic. As science reveals an enhanced understanding of biological processes …

Controlling the revolving and rotating motion direction of asymmetric hexameric nanomotor by arginine finger and channel chirality

P Guo, D Driver, Z Zhao, Z Zheng, C Chan, X Cheng - ACS nano, 2019 - ACS Publications
Nanomotors in nanotechnology are as important as engines in daily life. Many ATPases are
nanoscale biomotors classified into three categories based on the motion mechanisms in …

The role of JNK phosphorylation as a molecular target to enhance adenovirus replication, oncolysis and cancer therapeutic efficacy

SL Wechman, XM Rao… - Cancer Biology & …, 2018 - Taylor & Francis
Oncolytic adenoviruses (Ads) are cancer selective tumoricidal agents; however their
mechanism of Ad-mediated cancer cell lysis, or oncolysis, remains undefined. This report …

[PDF][PDF] РАЗРАБОТКА МОНОКЛОНАЛЬНЫХ АНТИТЕЛ К ГЕКСОНУ АДЕНОВИРУСОВ ЧЕЛОВЕКА

ИВ Амосова - influenza.spb.ru
В России ежегодно регистрируется около 50 миллионов случаев инфекционных
заболеваний. До 95% из них приходится на острые респираторные вирусные …

Characterization of a mutant oncolytic adenovirus and the role of jnk in enhancing virotherapy.

SL Wechman - 2017 - ir.library.louisville.edu
Oncolytic adenoviruses (Ads) have great therapeutic potential for lung cancer treatment.
Cancer selective E1b-deleted Ads are safe; however, their clinical cancer therapeutic …

Investigating the oncolytic properties of a group B adenovirus on cancer cells and its effects on the local immune response

H Calderon - 2017 - ora.ox.ac.uk
Oncolytic viruses are characterised by their ability to selectively infect and kill tumour cells.
Recently it has emerged that they can exert an additional anticancer mechanism stimulating …