The tetrahydro-β-carboline (THBC) nucleus is a predominant feature of a vast array of
naturally occurring alkaloids. Most of these alkaloids have been found to exhibit significant …

The β-carboline skeleton is prevalent in a vast collection of naturally present alkaloids. Most
of these alkaloids and their derivatives have been found to show significant biological …

The development of cost-effective and sustainable catalytic methods for the production of
enantiomerically pure chiral amines is a key challenge facing the pharmaceutical and fine …

The discovery of an orally bioavailable selective estrogen receptor downregulator (SERD)
with equivalent potency and preclinical pharmacology to the intramuscular SERD fulvestrant …

A series of 1-indolyl substituted β-carbolines including the natural products
hyrtiosulawesine, pityriacitrin and pityriacitrin B were prepared via Pictet–Spengler …

The increasing importance of enzyme mimics in organic synthesis inspired us to design a
novel biomimetic synthesis of β-carboline alkaloids directly from tryptophan and a second …

Tetrafluoroalkyl bromides are metalated with equimolar i PrMgCl· LiCl (Turbo Grignard) to
form organomagnesium compounds which are stable at low temperatures and react with …

A rapid, microwave-assisted synthesis of β-carbolines via a successive condensation/
cyclization/dehydrogenation approach is described. This methodology involves the coupling …

A series of different 1-monosubstituted and 1, 1-disubstituted 1, 2, 3, 4-tetrahydro-
isoquinolines was synthesized in high yields from different ketoamides. We have developed …

An efficient, practical, and general method for conversions of N‐tosyltetrahydroisoquinolines
(N‐tosyl‐THIQs) into isoquinolines and of N‐tosyltetrahydro‐β‐carbolines (N‐tosyl‐THBCs) …