Purpose Distinguishing radiation necrosis (RN) from recurrent tumor remains a vexing
clinical problem with important health-care consequences for neuro-oncology patients …

Background Radionecrosis is a common complication in radiation oncology, while
mechanisms and risk factors have yet to be fully explored. We therefore conducted a …

Purpose To develop a Gamma Knife-based mouse model of late time-to-onset, cerebral
radiation necrosis (RN) with serial evaluation by magnetic resonance imaging (MRI) and …

Purpose The analysis of biological and mesoscopic structures properties by diffusion MRI
(dMRI) in brain after radiation therapy remains challenging. In our study, we described the …

Purpose Clinical evidence suggests radiation induces changes in the brain
microenvironment that affect subsequent response to treatment. This study investigates the …

Purpose: To provide a comprehensive understanding of how the selection of radiation dose
affects the temporal and spatial progression of radiation-induced necrosis in the rat model …

Anti-vascular endothelial growth factor (anti-VEGF) antibodies are a promising new
treatment for late time-to-onset radiation-induced necrosis (RN). We sought to evaluate and …

Cerebral involvement especially brain abscess is life‐threatening complication and major
cause of death during Scedosporium apiospermum infection. However, little is known about …

Purpose The radiation dose delivered to brain tumors is limited by the possibility to induce
vascular damage and necrosis in surrounding healthy tissue. In the present study, we …

Recently, radiation induced necrosis in the brain has been treated using bevacizumab, an
anti-VEGF antibody. We validated the VEGF specificity by comparing the therapeutic efficacy …