The use of natural products has been shown to be a fruitful approach in the discovery of
novel pharmaceuticals. In fact, many currently approved drugs originated from compounds …

Natural products and their derivatives are a rich source for drug discovery. Meanwhile, cell
membrane has emerged as an effective tool to screen the active compounds from natural …

Cancer is the second leading cause of death in the world and its incidence is expected to
increase with the aging of the world's population and globalization of risk factors. Natural …

Tropomyosin kinase receptor B (TrkB) has been explored as a therapeutic target for
neurological and psychiatric disorders. However, the development of TrkB agonists was …

The ability to identify unknown risks is the key to improving the level of food safety. However,
the conventional nontargeted screening methods for new contaminant identification and risk …

Being the highest expressed neurotrophin in the mammalian brain, the brain‐derived
neurotrophic factor (BDNF) is essential to neural development and plasticity in both health …

由于中药化学成分的复杂性以及作用机制的不明确性, 采用合适的方法对中药活性成分进行筛选
, 以及对药效物质基础进行解析是中药研究需要面对的关键挑战. 近年来, 基于天然细胞膜靶向 …

In this chapter, the principles and processes of bio-specific extraction/receptor fishing, such
as equilibrium dialysis, centrifugation, and material-based ligand screening assay, are …