Primary cilia are microtubule-based organelles that extend from the apical surface of most
mammalian cells, forming when the basal body (derived from the mother centriole) docks at …

Cisplatin and other platinum (II) analogs are widely used in clinical practice as anti-cancer
drugs for a wide range of tumors. The primary mechanism by which they exert their action is …

Recent observations related to the structure of the cytoskeleton in neurons and novel
cytoskeletal abnormalities involved in the pathophysiology of some neurological diseases …

Glioblastoma (GBM) is an aggressive, fatal and malignant primary brain tumor. Despite the
current standard treatment for glioblastoma patients including neurosurgical resection …

The aggregation of alpha-synuclein (α-Syn) plays a critical role in the development of
Parkinson's disease (PD) and other synucleinopathies. α-Syn, which is encoded by the …

Cortactin, a substrate of sarcoma (Src) kinases, is an actin-binding protein that is involved in
cytoskeletal regulation, and is frequently overexpressed in cancer cells. Binding to the actin …

The actin cytoskeleton regulates many important cellular processes in the brain, including
cell division and proliferation, migration, and cytokinesis and differentiation. These …

The non-catalytic region of tyrosine kinase (Nck) family of adaptors, consisting of Nck1 and
Nck2, contributes to selectivity and specificity in the flow of cellular information by recruiting …

Biochemical reactions often occur at low copy numbers but at once in crowded and diverse
environments. Space and stochasticity therefore play an essential role in biochemical …

TFE3 is a member of the basic helix–loop–helix leucine zipper MiT transcription factor
family, and its chimeric proteins are associated with translocation renal cell carcinoma …