Metabolic alterations upon SARS-CoV-2 infection and potential therapeutic targets against coronavirus infection

P Chen, M Wu, Y He, B Jiang, ML He - Signal Transduction and …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) caused by coronavirus SARS-CoV-2
infection has become a global pandemic due to the high viral transmissibility and …

Potential anti-SARS-CoV-2 prodrugs activated by phosphorylation and their role in the aged population

VP Chavda, D Teli, PC Balar, D Vaghela, HK Solanki… - Molecules, 2023 - mdpi.com
The COVID-19 pandemic has flared across every part of the globe and affected populations
from different age groups differently. People aged from 40 to 80 years or older are at an …

Comparison of preprint postings of randomized clinical trials on COVID-19 and corresponding published journal articles: a systematic review

AD Bai, Y Jiang, DL Nguyen, CKL Lo… - JAMA Network …, 2023 - jamanetwork.com
Importance Randomized clinical trials (RCTs) on COVID-19 are increasingly being posted
as preprints before publication in a scientific, peer-reviewed journal. Objective To assess …

Metabolism of NK cells during viral infections

KY Osuna-Espinoza, AG Rosas-Taraco - Frontiers in Immunology, 2023 - frontiersin.org
Cellular metabolism is essential for the correct function of immune system cells, including
Natural Killer cells (NK). These cells depend on energy to carry out their effector functions …

2‐Deoxy‐D‐Glucose: A Novel Pharmacological Agent for Killing Hypoxic Tumor Cells, Oxygen Dependence‐Lowering in Covid‐19, and Other Pharmacological …

R Singh, V Gupta, A Kumar… - … in Pharmacological and …, 2023 - Wiley Online Library
The nonmetabolizable glucose analog 2‐deoxy‐D‐glucose (2‐DG) has shown promising
pharmacological activities, including inhibition of cancerous cell growth and N …

[HTML][HTML] The Impact of Glycolysis and Its Inhibitors on the Immune Response to Inflammation and Autoimmunity

B Pająk, R Zieliński, W Priebe - Molecules, 2024 - mdpi.com
Glucose metabolism is a crucial biological pathway maintaining the activation of extra-and
intracellular signaling pathways involved in the immune response. Immune cell stimulation …

Pyrolyzed deketene curcumin controls regulatory T cell generation and gastric cancer metabolism cooperate with 2-deoxy-d-glucose

T MaruYama, H Miyazaki, YJ Lim, J Gu… - Frontiers in …, 2023 - frontiersin.org
Pyrolyzed deketene curcumin GO-Y022 prevents carcinogenesis in a gastric cancer mouse
model. However, it is still less clear if GO-Y022 affects tumor-induced immune suppression …

Innate sensing and cellular metabolism: role in fine tuning antiviral immune responses

D Ahmed, M Al-Daraawi, E Cassol - Journal of Leukocyte …, 2023 - academic.oup.com
Several studies over the last decade have identified intimate links between cellular
metabolism and macrophage function. Metabolism has been shown to both drive and …

Glycolytic interference blocks influenza A virus propagation by impairing viral polymerase-driven synthesis of genomic vRNA

J Kleinehr, M Schöfbänker, K Daniel, F Günl… - PLoS …, 2023 - journals.plos.org
Influenza A virus (IAV), like any other virus, provokes considerable modifications of its host
cell's metabolism. This includes a substantial increase in the uptake as well as the …

Possible mechanisms of SARS-CoV-2-associated myocardial fibrosis: reflections in the post-pandemic era

Z Wang, L Li, S Yang, Z Li, P Zhang, R Shi… - Frontiers in …, 2024 - frontiersin.org
Since December 2019, coronavirus disease 2019 (COVID-19) has been spreading
worldwide with devastating immediate or long-term effects on people's health. Although the …