PTEN tumor-suppressor: the dam of stemness in cancer
F Luongo, F Colonna, F Calapà, S Vitale, ME Fiori… - Cancers, 2019 - mdpi.com
PTEN is one of the most frequently inactivated tumor suppressor genes in cancer. Loss or
variation in PTEN gene/protein levels is commonly observed in a broad spectrum of human …
variation in PTEN gene/protein levels is commonly observed in a broad spectrum of human …
Clinical development of phosphatidylinositol 3-kinase inhibitors for cancer treatment
I Brana, LL Siu - BMC medicine, 2012 - Springer
Abstract The phosphatidylinositol 3-kinase (PI3K) pathway is commonly deregulated in
cancer. In recent years, the results of the first phase I clinical trials with PI3K inhibitors have …
cancer. In recent years, the results of the first phase I clinical trials with PI3K inhibitors have …
PIK3CA Mutations in Patients with Advanced Cancers Treated with PI3K/AKT/mTOR Axis Inhibitors
F Janku, AM Tsimberidou, I Garrido-Laguna… - Molecular cancer …, 2011 - AACR
Preclinical data suggest that PIK3CA mutations predict response to PI3K/AKT/mTOR
inhibitors. Concomitant KRAS or BRAF mutations may mediate resistance. Therefore, tumors …
inhibitors. Concomitant KRAS or BRAF mutations may mediate resistance. Therefore, tumors …
Signaling networks associated with AKT activation in non-small cell lung cancer (NSCLC): new insights on the role of phosphatydil-inositol-3 kinase
Aberrant activation of PI3K/AKT signalling represents one of the most common molecular
alterations in lung cancer, though the relative contribution of the single components of the …
alterations in lung cancer, though the relative contribution of the single components of the …
The association of PI3 kinase signaling and chemoresistance in advanced ovarian cancer
CP Carden, A Stewart, P Thavasu, E Kipps… - Molecular cancer …, 2012 - AACR
Evidence that the phosphoinositide 3-kinase (PI3K) pathway is deregulated in ovarian
cancer is largely based on the analysis of surgical specimens sampled at diagnosis and …
cancer is largely based on the analysis of surgical specimens sampled at diagnosis and …
[HTML][HTML] HDAC5, a potential therapeutic target and prognostic biomarker, promotes proliferation, invasion and migration in human breast cancer
A Li, Z Liu, M Li, S Zhou, Y Xu, Y Xiao, W Yang - Oncotarget, 2016 - ncbi.nlm.nih.gov
Purpose Histone deacetylase 5 (HDAC5) is an important protein in neural and cardiac
diseases and a potential drug target. However, little is known regarding the specific role of …
diseases and a potential drug target. However, little is known regarding the specific role of …
OTUB1 promotes metastasis and serves as a marker of poor prognosis in colorectal cancer
Y Zhou, J Wu, X Fu, W Du, L Zhou, X Meng, H Yu, J Lin… - Molecular cancer, 2014 - Springer
Background OTUB1 (OTU deubiquitinase, ubiquitin aldehyde binding 1) is a
deubiquitinating enzyme (DUB) that belongs to the OTU (ovarian tumor) superfamily. The …
deubiquitinating enzyme (DUB) that belongs to the OTU (ovarian tumor) superfamily. The …
High expression of p300 in human breast cancer correlates with tumor recurrence and predicts adverse prognosis
X Xiao, M Cai, J Chen, X Guan, H Kung, Y Zeng… - Chinese Journal of …, 2011 - Springer
Objective Transcriptional coactivator p300 has been shown to play a variety of roles in the
transcription process and mutation of p300 has been found in certain types of human …
transcription process and mutation of p300 has been found in certain types of human …
Decreased expression of Beclin 1 correlates closely with Bcl-xL expression and poor prognosis of ovarian carcinoma
HX Lin, HJ Qiu, F Zeng, HL Rao, GF Yang, HF Kung… - PloS one, 2013 - journals.plos.org
Background It has been suggested that autophagy-related Beclin 1 plays a critical role in the
regulation of tumor development and/or progression, but its prognostic significance and …
regulation of tumor development and/or progression, but its prognostic significance and …
PTEN inhibits BMI1 function independently of its phosphatase activity
Background PTEN is the second most mutated tumor suppressor gene other than p53. It
suppresses tumorigenesis by dephosphorylating phosphatidylinositol (3, 4, 5)-triphosphate …
suppresses tumorigenesis by dephosphorylating phosphatidylinositol (3, 4, 5)-triphosphate …