The role of astrocytes in oxidative stress of central nervous system: A mixed blessing
Y Chen, C Qin, J Huang, X Tang, C Liu… - Cell …, 2020 - Wiley Online Library
Central nervous system (CNS) maintains a high level of metabolism, which leads to the
generation of large amounts of free radicals, and it is also one of the most vulnerable organs …
generation of large amounts of free radicals, and it is also one of the most vulnerable organs …
Effects of curcumin on mitochondria in neurodegenerative diseases
H Bagheri, F Ghasemi, GE Barreto, R Rafiee… - Biofactors, 2020 - Wiley Online Library
Neurodegenerative diseases (NDs) result from progressive deterioration of selectively
susceptible neuron populations in different central nervous system (CNS) regions. NDs are …
susceptible neuron populations in different central nervous system (CNS) regions. NDs are …
Inflammatory mechanisms and oxidative stress as key factors responsible for progression of neurodegeneration: role of brain innate immune system
J Leszek, GE Barreto, K Gasiorowski… - CNS & Neurological …, 2016 - ingentaconnect.com
Chronic inflammation is characterized by longstanding microglial activation followed by
sustained release of inflammatory mediators, which aid in enhanced nitrosative and …
sustained release of inflammatory mediators, which aid in enhanced nitrosative and …
Glutathione-dependent detoxification processes in astrocytes
R Dringen, M Brandmann, MC Hohnholt… - Neurochemical …, 2015 - Springer
Astrocytes have a pivotal role in brain as partners of neurons in homeostatic and metabolic
processes. Astrocytes also protect other types of brain cells against the toxicity of reactive …
processes. Astrocytes also protect other types of brain cells against the toxicity of reactive …
The effects of statins on microglial cells to protect against neurodegenerative disorders: A mechanistic review
Microglia are the primary innate immune system cells in the central nervous system (CNS).
They are crucial for the immunity, neurogenesis, synaptogenesis, neurotrophic support …
They are crucial for the immunity, neurogenesis, synaptogenesis, neurotrophic support …
Rotenone exerts developmental neurotoxicity in a human brain spheroid model
Growing concern suggests that some chemicals exert (developmental) neurotoxicity (DNT
and NT) and are linked to the increase in incidence of autism, attention deficit and …
and NT) and are linked to the increase in incidence of autism, attention deficit and …
[HTML][HTML] Biomolecular characterization of exosomes released from cancer stem cells: Possible implications for biomarker and treatment of cancer
Cancer recognized as one of the leading irrepressible health issues is contributing to
increasing mortality-rate day-by-day. The tumor microenvironment is an important field of …
increasing mortality-rate day-by-day. The tumor microenvironment is an important field of …
Metabolic and inflammatory adaptation of reactive astrocytes: role of PPARs
Astrocyte-mediated inflammation is associated with degenerative pathologies such as
Alzheimer's and Parkinson's diseases and multiple sclerosis. The acute inflammation and …
Alzheimer's and Parkinson's diseases and multiple sclerosis. The acute inflammation and …
Activation of the mitochondrial unfolded protein response: a new therapeutic target?
JM Suárez-Rivero, CJ Pastor-Maldonado… - Biomedicines, 2022 - mdpi.com
Mitochondrial dysfunction is a key hub that is common to many diseases. Mitochondria's role
in energy production, calcium homeostasis, and ROS balance makes them essential for cell …
in energy production, calcium homeostasis, and ROS balance makes them essential for cell …
Activation of α7 nicotinic acetylcholine receptors protects astrocytes against oxidative stress-induced apoptosis: implications for Parkinson's disease
Astrocytes have been implicated in the immune responses associated with Parkinson's
disease (PD). Inhibition of astrocyte apoptosis is a novel strategy for the treatment of PD …
disease (PD). Inhibition of astrocyte apoptosis is a novel strategy for the treatment of PD …